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Outcome of total hip arthroplasty in patients with Gaucher disease.

Abstract
This retrospective survey includes 29 total hip arthroplasties (THAs) in 23 patients with Gaucher disease, with heterogeneous techniques, with various prostheses, and performed by 9 different surgical teams. THA was discouraged in patients with Gaucher disease because of a tendency toward infection, poor bone matrix because of Gaucher cell infiltration, and deterioration of matrix with disease progression. Subjective assessment of pain and function, objective examination of outcome, and radiologic signs of loosening after THA were evaluated. In primary THAs, there was enhancement of quality of life, allowing restoration of full participation in normal activities; function was improved; radiologic evidence of loosening was low; and there were no infections. In revisions, the results were not as good. THA is recommended in this population using criteria comparable to those in other patients, with equally good results.
AuthorsE Lebel, M Itzchaki, I Hadas-Halpern, A Zimran, D Elstein
JournalThe Journal of arthroplasty (J Arthroplasty) Vol. 16 Issue 1 Pg. 7-12 (Jan 2001) ISSN: 0883-5403 [Print] United States
PMID11172263 (Publication Type: Journal Article)
Topics
  • Activities of Daily Living
  • Adolescent
  • Adult
  • Arthroplasty, Replacement, Hip (adverse effects)
  • Child
  • Female
  • Femur Head Necrosis (complications, surgery)
  • Gaucher Disease (complications, drug therapy, therapy)
  • Humans
  • Male
  • Osteoarthritis, Hip (complications)
  • Pain Measurement
  • Patient Satisfaction
  • Prosthesis Failure
  • Quality of Life
  • Reoperation
  • Retrospective Studies
  • Splenectomy
  • Treatment Outcome

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