Isolation of human faecal bifidobacteria which reduce signs of Salmonella infection when orogastrically dosed to mice.

Abstract

AIMS:

The aim of the study was to isolate human bifidobacteria that inhibit growth of Salmonella typhimurium in vitro, and provide protection against Salmonella infection in mice.

METHODS AND RESULTS:

A total of 92 micro-organisms, which displayed antagonist activity against Salm. typhimurium in vitro, were isolated from human faecal material. Based on their Gram stain status, cultures were pooled and tested for anti-Salmonella activity. The Gram-variable group was the most active. From that group, three bifidobacteria (Laftitrade markB22, B74 and B97) individually showed good pathogen inhibition in vivo.

CONCLUSION:

Oral administration of certain human bifidobacteria provides protection against Salmonella infection in mice.

SIGNIFICANCE AND IMPACT OF THE STUDY:

These results indicate that certain bifidobacteria may be used as a prophylaxis for reduced incidence and severity of Salmonella infections.

• Authors: A Henriksson, P L Conway
• Journal: Journal of applied microbiology (J Appl Microbiol) Vol. 90 Issue 2 Pg. 223-8 (Feb 2001) ISSN: 1364-5072 [Print] England
• PMID: 11168725 (Publication Type: Journal Article)

Topics

• Animals
• Antibiosis
• Bifidobacterium (growth & development, isolation & purification)
• Feces (microbiology)
• Female
• Humans
• Mice
• Mice, Inbred BALB C
• Salmonella Infections (microbiology, prevention & control)
• Salmonella typhimurium (growth & development)