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Topical gentian violet for cutaneous infection and nasal carriage with MRSA.

Abstract
This study describes a potential effect of topical gentian violet on cutaneous infection and nasal carriage with methicillin-resistant Staphylococcus aureus (MRSA). 0.5% gentian violet was used in 28 cases of skin lesions once a day, while a 0.3% solution was applied on the nasal vestibules of nine cases twice a day. The period for eradication in the 28 skin cases was 9.1 +/- 6.0 days. It was 15.3 +/- 9.0 days for the nine nasal lesions. The minimal inhibitory concentration (MIC) of gentian violet against MRSA from the four isolated strains was 0.0225 +/- 0.0096 microg/mL. No adverse reactions occurred throughout the study. It is suggested that gentian violet may be potentially effective against MRSA.
AuthorsM Okano, S Noguchi, K Tabata, Y Matsumoto
JournalInternational journal of dermatology (Int J Dermatol) Vol. 39 Issue 12 Pg. 942-4 (Dec 2000) ISSN: 0011-9059 [Print] England
PMID11168669 (Publication Type: Clinical Trial, Journal Article)
Chemical References
  • Anti-Infective Agents, Local
  • Gentian Violet
  • Methicillin
Topics
  • Administration, Topical
  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Anti-Infective Agents, Local (administration & dosage, therapeutic use)
  • Child
  • Child, Preschool
  • Female
  • Gentian Violet (administration & dosage, therapeutic use)
  • Humans
  • Infant
  • Male
  • Methicillin (pharmacology)
  • Methicillin Resistance
  • Microbial Sensitivity Tests
  • Middle Aged
  • Nasal Cavity (microbiology)
  • Prospective Studies
  • Staphylococcal Skin Infections (drug therapy, microbiology)
  • Staphylococcus aureus (drug effects, isolation & purification)

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