Abstract |
Sixty patients with moderate and severe burns were randomly assigned to receive topical silver sulfadiazine ( SSD) alone ( n=30) or SSD combined with cerium nitrate ( SSD-CN) ( n=30). There were four deaths in the SSD group and one in the SSD-CN group; more patients with higher risk severity survived in the SSD-CN group. Wound infection did not differ significantly between the groups. The rate of re-epithelialization of partial thickness burns was faster by 8 days in the SSD-CN group. The relatively dry shell-like eschar of the SSD-CN-treated burn allowed planned excisions with immediate autologous grafting and the tissue beneath was ready to accept grafting 11 days earlier than in the SSD group (p=0.03). This resulted in a significantly shorter hospital stay for those in the SSD-CN group than in the SSD group (23.3 vs. 30.7 days; p=0.03) with consequent cost savings. A higher incidence of transient stinging pain was reported with application of SSD-CN, but this was effectively managed with analgesics where necessary. The results of this study confirm the greater efficacy of SSD-CN in the treatment of burns patients.
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Authors | C G de Gracia |
Journal | Burns : journal of the International Society for Burn Injuries
(Burns)
Vol. 27
Issue 1
Pg. 67-74
(Feb 2001)
ISSN: 0305-4179 [Print] Netherlands |
PMID | 11164668
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Anti-Infective Agents, Local
- cerium nitrate
- Cerium
- Silver Sulfadiazine
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Topics |
- Administration, Topical
- Adolescent
- Adult
- Anti-Infective Agents, Local
(administration & dosage)
- Burns
(drug therapy, mortality, surgery)
- Cerium
(administration & dosage)
- Child
- Child, Preschool
- Drug Therapy, Combination
- Female
- Humans
- Length of Stay
- Male
- Middle Aged
- Patient Dropouts
- Silver Sulfadiazine
(administration & dosage)
- Skin Transplantation
- Treatment Outcome
- Wound Healing
(drug effects)
- Wound Infection
(prevention & control)
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