Correlation between increased airway responsiveness and severity of pulmonary edema.

Abstract

To determine whether the severity of the pulmonary edema in sheep models of cardiogenic and non-cardiogenic pulmonary edema correlate with concomitant alterations in airway responsiveness using three separate measures of pulmonary edema: post-mortem wet-to-dry lung weight ratio (W/D), chest radiograph (CXR) scores, and small airway wall area. Cardiogenic pulmonary edema was induced by increasing left atrial pressure (increase PLA) and non-cardiogenic pulmonary edema was induced by intravenous administration of Perilla ketone (PK). There was a significant negative correlation between changes in airway responsiveness and changes in CXR grade (r=-0.749, P<0.05), W/D (r=-0.662, P<0.05), airway wall areas (r=0.784, P<0.05) after increases in both PLA and PK. Chest radiograph score, W/D, and airway wall area correlated with each other (CXR score and W/D r=0.657, P<0.05; CXR score and airway wall area r=0.678, P<0.05; airway wall area and W/D r=0.704, P<0.05). We speculate that the increased airway responsiveness observed during pulmonary edema may result from the mechanical effects of edema formation within the airways.

• Authors: Y S Hwang, P L Lefferts, J R Snapper
• Journal: Pulmonary pharmacology & therapeutics (Pulm Pharmacol Ther) Vol. 14 Issue 1 Pg. 47-53 ( 2001) ISSN: 1094-5539 [Print] England
• PMID: 11162419 (Publication Type: Journal Article)

Topics

• Airway Resistance (physiology)
• Animals
• Asthma (physiopathology)
• Autopsy (veterinary)
• Biometry
• Bronchi (anatomy & histology, physiology)
• Disease Models, Animal
• Female
• Male
• Pulmonary Edema (drug therapy, physiopathology)
• Radiography, Thoracic
• Respiratory Distress Syndrome
• Severity of Illness Index
• Sheep