Abstract | OBJECTIVE: METHODS/RESULTS: Two patients undergoing surgical prophylaxis to address an increase in ovarian cancer risk were discovered to harbor occult primary fallopian tube carcinoma on final pathology review. Mutational analysis confirmed the presence of a deleterious mutation in BRCA-1 in both patients. CONCLUSION: Currently, consensus opinions regarding ovarian cancer surgical prophylaxis in gene mutation carriers do not include hysterectomy as part of the preventative procedure. This report as well as a growing number of cases of fallopian tube cancer reported in known BRCA-1 and BRCA-2 mutation carriers has important implications for recommendations regarding surgical prophylaxis in these women.
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Authors | P J Paley, E M Swisher, R L Garcia, S N Agoff, B E Greer, K L Peters, B A Goff |
Journal | Gynecologic oncology
(Gynecol Oncol)
Vol. 80
Issue 2
Pg. 176-80
(Feb 2001)
ISSN: 0090-8258 [Print] United States |
PMID | 11161856
(Publication Type: Case Reports, Journal Article, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- BRCA2 Protein
- Neoplasm Proteins
- Transcription Factors
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Topics |
- BRCA2 Protein
- Fallopian Tube Neoplasms
(genetics, surgery)
- Female
- Genes, BRCA1
(genetics)
- Genetic Predisposition to Disease
- Germ-Line Mutation
- Humans
- Hysterectomy
- Middle Aged
- Neoplasm Proteins
(genetics)
- Ovarian Neoplasms
(genetics, prevention & control, surgery)
- Ovariectomy
- Pedigree
- Transcription Factors
(genetics)
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