Abstract |
Mice bearing either of the two rapidly growing mouse leukemias, L1210 or P388, or the slow-growing B16 melanoma responded to i.p. injections of Macromomycin B ( NSC 170105) with significant increases in life-span. The maximal increases in life-span obtained in these experiments were 37% for L1210, 68% for P388, and 120% for B16. In addition, there were 7 of 30 cures for varying doses of Macromomycin in the B16 melanoma. Activity of over 50% increase in life-span in B16 was obtained with a daily i.p. injection on Days 1 to 9 of 16 to 40 mg/kg. Animals that had received s.c. implanted Lewis lung tumors responded to either single or repeated injections (8 to 16 mg/kg) given at the site of tumor implant by a marked reduction in growth of the primary tumor, increased life-span, and some cures. The same doses were without effect when administered i.p. The reported activity of Macromomycin against L1210, P388 leukemias, B16 melanoma, and Lewis lung carcinoma make it a good candidate for development for clinical trial against human solid tumors. A new method of evaluating activity against solid tumors, "responder analysis," is also presented.
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Authors | M M Lippman, W R Laster, B J Abbott, J Venditti, M Baratta |
Journal | Cancer research
(Cancer Res)
Vol. 35
Issue 4
Pg. 939-45
(Apr 1975)
ISSN: 0008-5472 [Print] United States |
PMID | 1116151
(Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Antibiotics, Antineoplastic
- Bacterial Proteins
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Topics |
- Animals
- Antibiotics, Antineoplastic
(administration & dosage, therapeutic use)
- Bacterial Proteins
(therapeutic use)
- Evaluation Studies as Topic
- Leukemia L1210
(drug therapy)
- Leukemia, Experimental
(drug therapy)
- Lung Neoplasms
(drug therapy)
- Melanoma
(drug therapy)
- Mice
- Mice, Inbred BALB C
- Mice, Inbred C57BL
- Mice, Inbred DBA
- Neoplasm Transplantation
- Neoplasms, Experimental
(drug therapy)
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