Abstract |
Patients with breast carcinoma were screened for abnormal concentrations of CEA, HCG, putrescine, spermidine, spermine, pseudouridine, N2, N2-dimethylguanosine, and 1-methylinosine. Abnormal polyamine levels occurred in less than 15% of the patients. Among the nucleosides, N2, N2-dimethylguanosine was the most frequently abnormal, occurring in 57% of the patients with metastatic disease. CEA levels were abnormal in 30% of postoperative N+ patients and 74% of patients with metastatic disease, while HCG elevations were found in 45% and 50%, respectively. All the patients with one or more marker abnormalities could be detected by measuring only CEA, N2, N2-dimethylguanosine, and HCG. Among these three tests, a singular marker abnormality occurred in 35.8% of the patients, and all three tests were abnormal in 21.8% of the patients. The performance of these three tests in each patient revealed one or more abnormalities 97% of the patients with metastatic disease, and 67% of the postoperative N+ patients.
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Authors | D C Tormey, T P Waalkes, D Ahmann, C W Gehrke, R W Zumwatt, J Snyder, H Hansen |
Journal | Cancer
(Cancer)
Vol. 35
Issue 4
Pg. 1095-100
(Apr 1975)
ISSN: 0008-543X [Print] United States |
PMID | 1116102
(Publication Type: Journal Article)
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Chemical References |
- Carcinoembryonic Antigen
- Chorionic Gonadotropin
- Nucleosides
- Polyamines
- Guanosine
- Pseudouridine
- Inosine
- Spermidine
- Putrescine
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Topics |
- Breast Neoplasms
(blood, immunology)
- Carcinoembryonic Antigen
(analysis)
- Chorionic Gonadotropin
(blood)
- Female
- Guanosine
(analogs & derivatives, blood)
- Humans
- Inosine
(analogs & derivatives, blood)
- Neoplasm Metastasis
- Nucleosides
(blood)
- Polyamines
(blood)
- Pseudouridine
(blood)
- Putrescine
(blood)
- Spermidine
(blood)
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