Therapeutic potential of human neutrophil peptide 1 against experimental tuberculosis.

• Abstract: The therapeutic efficacy of human neutrophil peptide 1 (HNP-1) against experimental tuberculosis in mice on the basis of numbers of CFU has been examined. Mice infected with 1.5 x 10(4) CFU of Mycobacterium tuberculosis H(37)Rv and treated with different doses of HNP-1 injected subcutaneously exhibited significant clearance of bacilli from lungs, livers, and spleens. There were time- and dose-dependent decreases in the bacillary load in lungs, livers, and spleens of the HNP-1-treated animals compared to that in controls (untreated animals). These observations strongly suggest the therapeutic activity of HNP-1 against tuberculosis.
• Authors: S Sharma, I Verma, G K Khuller (Affiliation: Department of Biochemistry, Postgraduate Institute of Medical Education & Research, Chandigarh, India.)
• Journal: Antimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 45 Issue 2 Pg. 639-40 (Feb 2001) ISSN: 0066-4804 [Print] United States
• PMID: 11158773 (Publication Type: Journal Article)

Chemical References

• Anti-Infective Agents
• alpha-Defensins
• human neutrophil peptide 1

Topics

• Animals
• Anti-Infective Agents (therapeutic use)
• Colony Count, Microbial
• Humans
• Liver (microbiology)
• Lung (microbiology)
• Mice
• Mice, Inbred Strains
• Spleen (microbiology)
• Time Factors
• Tuberculosis (drug therapy, microbiology)
• alpha-Defensins (therapeutic use)