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Efficacy of the partricin derivative SPA-S-753 against systemic murine candidosis.

Abstract
The polyene partricin compound SPA-S-753 (Societa Prodotti Antibiotici, Milano, Italy) was assessed in a murine model of systemic candidosis. CD-1 mice were infected iv with Candida albicans and treated iv with SPA-S-753 or amphotericin B. All treatment regimens of SPA-S-753 or amphotericin B were equivalent and significantly prolonged survival compared with controls (P < 0.001). Amphotericin B and SPA-S-753 significantly reduced burdens of C. albicans in the spleen and kidneys. Overall, cure rates were similar, amphotericin B at 1 mg/kg cured three and SPA-S-753 at 10 mg/kg cured four mice of infection in both organs. The efficacy of SPA-S-753 is between equivalent and <10-fold as potent as amphotericin B. These results are encouraging and warrant further studies on SPA-S-753.
AuthorsK V Clemons, D A Stevens
JournalThe Journal of antimicrobial chemotherapy (J Antimicrob Chemother) Vol. 47 Issue 2 Pg. 183-6 (Feb 2001) ISSN: 0305-7453 [Print] England
PMID11157903 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antifungal Agents
  • Polyenes
  • SPA-S-753
  • partricin
  • Amphotericin B
Topics
  • Amphotericin B (administration & dosage, therapeutic use)
  • Animals
  • Antifungal Agents (administration & dosage, therapeutic use)
  • Candida albicans (drug effects)
  • Candidiasis (drug therapy, microbiology)
  • Injections, Intravenous
  • Kidney (microbiology)
  • Mice
  • Microbial Sensitivity Tests
  • Polyenes (administration & dosage, pharmacology)
  • Spleen (microbiology)

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