Abstract |
The polyene partricin compound SPA-S-753 (Societa Prodotti Antibiotici, Milano, Italy) was assessed in a murine model of systemic candidosis. CD-1 mice were infected iv with Candida albicans and treated iv with SPA-S-753 or amphotericin B. All treatment regimens of SPA-S-753 or amphotericin B were equivalent and significantly prolonged survival compared with controls (P < 0.001). Amphotericin B and SPA-S-753 significantly reduced burdens of C. albicans in the spleen and kidneys. Overall, cure rates were similar, amphotericin B at 1 mg/kg cured three and SPA-S-753 at 10 mg/kg cured four mice of infection in both organs. The efficacy of SPA-S-753 is between equivalent and <10-fold as potent as amphotericin B. These results are encouraging and warrant further studies on SPA-S-753.
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Authors | K V Clemons, D A Stevens |
Journal | The Journal of antimicrobial chemotherapy
(J Antimicrob Chemother)
Vol. 47
Issue 2
Pg. 183-6
(Feb 2001)
ISSN: 0305-7453 [Print] England |
PMID | 11157903
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antifungal Agents
- Polyenes
- SPA-S-753
- partricin
- Amphotericin B
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Topics |
- Amphotericin B
(administration & dosage, therapeutic use)
- Animals
- Antifungal Agents
(administration & dosage, therapeutic use)
- Candida albicans
(drug effects)
- Candidiasis
(drug therapy, microbiology)
- Injections, Intravenous
- Kidney
(microbiology)
- Mice
- Microbial Sensitivity Tests
- Polyenes
(administration & dosage, pharmacology)
- Spleen
(microbiology)
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