[Resistance and new antibiotic strategies. New antistaphylococcal antibiotics].

Abstract

INJECTABLE SPECTROGRAMIN: Combination regimens using quinupristin/dafopristin with either gentamicin or vancomycin have powerful bactericidal activities (even against quinupristin-resistant strains) against methicillin-resistant Staphylococcus aureus (MRSA) in a model of experimental endocarditis in the rabbit. In clinical trials, quinupristin/dalfopristin is becoming a therapeutic alternative to consider after failure of conventional antistaphylococcal treatments. NEW GENERATION CEPHALOSPORINS: These new cephalosporins, particularly C-3 pyridinium-thiomethyl-cephalosporins, new (3-dithiocarbamoyl) cephalosporins, and a series of new compounds with high affinity for MRSA PLP2a, are particularly active against MRSA and are unaffected by beta-lactamases. A NEW CARBAPENEM: This new antibiotic has a wide bactericidal effect against Gram-positive organisms and is active against MRSA as well as penicillin-resistant S. pneumoniae. NEW FLUOROQUINOLONE DERIVATIVES: In vitro, these new derivatives have been found to be active against MRSA, pneumococci non-sensitive to ciprofloxacin, and Bacteroides fragilis, Mycobacterium tuberculosis, Chlamydia pneumoniae.

• Authors: E Bergogne-Bérézin
• Journal: Presse medicale (Paris, France : 1983) (Presse Med) Vol. 29 Issue 37 Pg. 2023-7 (Dec 02 2000) ISSN: 0755-4982 [Print] France
• Vernacular Title: Résistances et nouvelles stratégies antibiotiques. Nouveaux antibiotiques antistaphylococciques.
• PMID: 11155724 (Publication Type: English Abstract, Journal Article, Review)

Chemical References

• Anti-Infective Agents
• Carbapenems
• Cephalosporins
• Fluoroquinolones
• Virginiamycin
• quinupristin-dalfopristin

Topics

• Anti-Infective Agents (therapeutic use)
• Carbapenems (therapeutic use)
• Cephalosporins (therapeutic use)
• Drug Therapy, Combination (therapeutic use)
• Endocarditis, Bacterial (drug therapy, microbiology)
• Fluoroquinolones
• Humans
• Methicillin Resistance
• Staphylococcal Infections (drug therapy, microbiology)
• Virginiamycin (therapeutic use)