Differential in situ distribution of interleukin-8, monocyte chemoattractant protein-1 and Rantes in human chronic periapical granuloma.

Abstract

In situ distribution of three prototype chemokines interleukin (IL)-8, monocyte chemoattractant protein (MCP)-1 and Rantes was determined in chronic human periapical granulomas by immunohistochemistry using monoclonal antibodies. IL-8 was found primarily in the cytoplasm of the Malassez epithelial cells. MCP-1 immunoreactivity was confined to the endothelial cells that lined small venules. Each of the three investigated chemokines, including Rantes, exhibited a characteristic binding pattern to the extracellular matrix of the lesion. The observed chemokines may play a role in establishing the cellular composition of chronic apical periodontitis, thus augmenting the intensity of local inflammation and tissue damage.

• Authors: I J Marton, A Rot, E Schwarzinger, S Szakáll, T Radics, I Vályi-Nagy, C Kiss
• Journal: Oral microbiology and immunology (Oral Microbiol Immunol) Vol. 15 Issue 1 Pg. 63-5 (Feb 2000) ISSN: 0902-0055 [Print] Denmark
• PMID: 11155167 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Chemokine CCL2
• Chemokine CCL5
• Chemokines
• Interleukin-8

Topics

• Chemokine CCL2 (analysis, metabolism)
• Chemokine CCL5 (analysis, metabolism)
• Chemokines (analysis, metabolism)
• Chemotaxis, Leukocyte
• Chronic Disease
• Epithelial Cells (immunology, metabolism)
• Humans
• Interleukin-8 (analysis, metabolism)
• Periapical Granuloma (immunology, metabolism, pathology)