Osteonecrosis of the femoral head after allogeneic bone marrow transplantation.

Abstract	A comparative retrospective analysis of 100 consecutive patients after bone marrow transplantation was performed with magnetic resonance imaging in addition to plain radiography for the development of osteonecrosis of the femoral head. The incidence and risk factors for osteonecrosis of the femoral head were identified, comparing various parameters concerning bone marrow transplantation between the groups with and without evidence of osteonecrosis. Nineteen (19%) of 100 patients had osteonecrosis of the femoral head develop. Four factors were found to be statistically significantly different between patients who had osteonecrosis develop and those who did not: younger age at the time of bone marrow transplantation, chronic graft-versus-host disease, cumulative dose of steroid, and intravenous pulse therapy with methylprednisolone. It was concluded that a low rate of complications and low dose steroid administration would reduce the incidence of osteonecrosis after bone marrow transplantation.
Authors	Y Torii, Y Hasegawa, T Kubo, Y Kodera, S Minami, Y Morishita, Y Yamada, H Iwata
Journal	Clinical orthopaedics and related research (Clin Orthop Relat Res) Issue 382 Pg. 124-32 (Jan 2001) ISSN: 0009-921X [Print] United States
PMID	11153979 (Publication Type: Comparative Study, Journal Article)
Chemical References	Glucocorticoids Immunosuppressive Agents Methylprednisolone
Topics	Adolescent Adult Age Factors Anemia, Aplastic (therapy) Bone Marrow Transplantation (adverse effects, diagnostic imaging, pathology) Chi-Square Distribution Female Femur Head Necrosis (diagnosis, diagnostic imaging, etiology) Glucocorticoids (administration & dosage, adverse effects) Graft vs Host Disease (complications) Humans Immunosuppressive Agents (therapeutic use) Incidence Injections, Intravenous Leukemia, Myelogenous, Chronic, BCR-ABL Positive (therapy) Leukemia, Myeloid, Acute (therapy) Logistic Models Magnetic Resonance Imaging Male Methylprednisolone (administration & dosage, adverse effects) Middle Aged Multivariate Analysis Precursor Cell Lymphoblastic Leukemia-Lymphoma (therapy) Radiography Retrospective Studies Risk Factors Statistics, Nonparametric Transplantation, Homologous

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