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Long-term follow-up of a randomized study of primary stenting versus angioplasty in acute myocardial infarction.

AbstractPURPOSE:
Primary stenting leads to better short-term outcomes than does balloon angioplasty among patients with acute myocardial infarction, but there are no data available on long-term follow-up.
SUBJECTS AND METHODS:
We designed a randomized study with long-term follow-up to compare primary angioplasty with angioplasty accompanied by implantation of a silicon carbide-coated stent in patients within 24 hours after the onset of acute myocardial infarction. All 88 patients had lesions that were suitable for coronary stenting.
RESULTS:
There were 44 patients in each of the randomization groups. During long-term follow-up (mean +/- SD: 710+/-282 days), primary stenting was associated with a reduction in the combined endpoint of death, reinfarction, or target vessel revascularization (10 [23%] versus 19 [43%], P = 0.03); death (4 [9%] versus 8 [18%], P = 0.18); reinfarction (1 [2%] versus 4 [9%], P = 0.18); and target lesion revascularization (7 [16%] versus 15 [34%], P = 0.04). Rehospitalization due to ischemic events (unstable angina or reinfarction) was also less frequent in the stent group (6 [14%] versus 10 [23%], P = 0.20).
CONCLUSION:
Primary stenting in acute myocardial infarction is significantly superior to angioplasty alone in both short-term and long-term follow-up.
AuthorsB Scheller, B Hennen, S Severin-Kneib, C Ozbek, H Schieffer, T Markwirth
JournalThe American journal of medicine (Am J Med) Vol. 110 Issue 1 Pg. 1-6 (Jan 2001) ISSN: 0002-9343 [Print] United States
PMID11152857 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
Topics
  • Aged
  • Angioplasty, Balloon, Coronary
  • Coronary Artery Bypass
  • Electrocardiography
  • Female
  • Follow-Up Studies
  • Humans
  • Male
  • Middle Aged
  • Myocardial Infarction (enzymology, mortality, therapy)
  • Patient Readmission
  • Recurrence
  • Stents
  • Time Factors
  • Treatment Outcome

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