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Cascara sagrada-induced intrahepatic cholestasis causing portal hypertension: case report and review of herbal hepatotoxicity.

Abstract
Herbal medicines are gaining widespread popularity. Much of the public believes that botanical herbs are both harmless and useful for the treatment of a variety of symptoms. This belief stands in contrast with the fact that many herbal therapies have been shown to be toxic. In the present case report, cascara sagrada (CS) has been associated with the development of cholestatic hepatitis, complicated by portal hypertension. CS is a mixture of ingredients, among which is anthracene glycoside--an herbal agent that previously has been associated with chronic hepatitis. The liver injury in the case herein reported is believed to be related to either anthracene glycoside or one of the other constituents of CS.
AuthorsA Nadir, D Reddy, D H Van Thiel
JournalThe American journal of gastroenterology (Am J Gastroenterol) Vol. 95 Issue 12 Pg. 3634-7 (Dec 2000) ISSN: 0002-9270 [Print] United States
PMID11151906 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Cathartics
Topics
  • Biopsy
  • Cathartics (adverse effects)
  • Chemical and Drug Induced Liver Injury (etiology, pathology)
  • Cholestasis, Intrahepatic (chemically induced, complications, pathology)
  • Humans
  • Hypertension, Portal (etiology, pathology)
  • Liver (drug effects, pathology)
  • Male
  • Middle Aged
  • Phytotherapy
  • Rhamnus (adverse effects)

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