[Antiinflammatory capacity of topical ketorolac in experimental model of ocular inflammation].

Abstract

PURPOSE:

We studied the antiinflammatory effect of topical Ketorolac-Tromethamine on a model of endotoxin-induced uveitis in albino rabbits.

METHODS:

Endotoxin-induced uveitis was produced by intravitreal injection in the right eye of 10 ng lipopolysaccharide (LPS) A Salmonella typhimurium endotoxin in 5 microl saline solution. We have used 60 animals (5 groups of 12 animals each). Control group (G-I) was injected with saline (5 microl); endotoxin group (G-II) was injected with 10 ng of endotoxin; groups III, IV and V were injected with the same amount of endotoxin and treated with topical ketorolac-tromethamine every 6, 4 and 2 hours respectively. The animals were sacrificed 24 hours after endotoxin administration. We determined the ocular clinical signs and inflammatory cells and protein concentration in the aqueous humor.

RESULTS:

In all the groups treated with Ketorolac-Tromethamine we observed a significant reduction (p<0.05) in all parameters studied when compared with those of the endotoxin group (G-II).

CONCLUSION:

Topical Ketorolac-Tromethamine has demonstrated a significant reduction of endotoxin-induced-uveitis inflammation.

• Authors: O R Moreno, R C Andrés, L P Júlvez, V P Llorens, D Marín Del Tiempo, E F Novella, C Torrón, F M Honrubia
• Journal: Archivos de la Sociedad Espanola de Oftalmologia (Arch Soc Esp Oftalmol) Vol. 75 Issue 5 Pg. 333-8 ( 2000) ISSN: 0365-6691 [Print] Spain
• Vernacular Title: Capacidad antiinflamatoria del Ketorolaco tópico en un modelo experimental de inflamación ocular.
• PMID: 11151171 (Publication Type: English Abstract, Journal Article)

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal
• Ketorolac

Topics

• Animals
• Anti-Inflammatory Agents, Non-Steroidal (therapeutic use)
• Drug Evaluation, Preclinical
• Female
• Ketorolac (therapeutic use)
• Male
• Rabbits
• Uveitis (drug therapy, etiology)