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[Effect of Ruboxyl (nitroxyl derivative of daunorubicin) on hepatic metastases of colorectal carcinoma].

Abstract
Inhibition by ruboxyl, a nitroxyl derivative of daunorubicin, source preparation and 5-fluorouracil was compared in metastases of experimental colorectal carcinoma to murine liver. The indices of metastasis inhibition were 84.43 and 70%, respectively. In rats receiving the drugs by continuous intravenous infusion for 7 days, the number of metastases was reduced (ruboxyl--1.0 +/- 1.4; 5-fluorouracil 3.2 +/- 1.3.
AuthorsN P Konovalova, L M Volkova, D Codacci-Pisanelli, P Seminara, F Franchi
JournalVoprosy onkologii (Vopr Onkol) Vol. 46 Issue 4 Pg. 438-41 ( 2000) ISSN: 0507-3758 [Print] Russia (Federation)
Vernacular TitleAktivnost' Ruboxyla (nitroxil'nogo proizvodnogo daunomitsina) pri metastazakh v pechen' kolorektal'nogo raka.
PMID11147420 (Publication Type: English Abstract, Journal Article)
Chemical References
  • Antibiotics, Antineoplastic
  • Antimetabolites, Antineoplastic
  • ruboxyl
  • Fluorouracil
  • Daunorubicin
Topics
  • Animals
  • Antibiotics, Antineoplastic (administration & dosage, pharmacology)
  • Antimetabolites, Antineoplastic (pharmacology)
  • Colorectal Neoplasms (pathology)
  • Daunorubicin (administration & dosage, analogs & derivatives, pharmacology)
  • Fluorouracil (pharmacology)
  • Infusions, Intravenous
  • Liver Neoplasms (drug therapy, prevention & control, secondary)
  • Mice
  • Rats

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