Interleukin (IL-)15 has less activity than IL-2 to promote type 2 cytokine predominance in tumour-associated mononuclear cells from lung cancer patients.

Abstract

Deviation of type 1/type 2 cytokine balance to type 2 predominance may contribute to tumour progression. We investigated effect of interleukin (IL-)15 on modulation of type 1/type 2 balance in addition to non-major histo-compatibility complex (MHC)-restricted killer induction in the tumour-growing site. IL-15 induced significant killer activity in mononuclear cells (MNC) in malignant pleural effusion as well as those in peripheral blood. Pleural MNC produced more IFN-gamma (type 1 cytokine) by incubation with IL-15 or IL-2 than blood MNC. Moreover, IL-4 and IL-5 (type 2 cytokines) production by pleural MNC were observed only by incubation with IL-2, but not with IL-15. These observations suggest that IL-15 has a potent activity to restore type 1/type 2 balance in addition to killer induction in tumour-growing site.

• Authors: E Takeuchi, H Yanagawa, Y Suzuki, K Shinkawa, H Bando, S Sone
• Journal: Cytokine (Cytokine) Vol. 13 Issue 2 Pg. 119-23 (Jan 21 2001) ISSN: 1043-4666 [Print] England
• PMID: 11145853 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright 2001 Academic Press.

Chemical References

• Interleukin-15
• Interleukin-2
• Interleukin-5
• Interleukin-4
• Interferon-gamma

Topics

• Adult
• Aged
• Aged, 80 and over
• Burkitt Lymphoma (metabolism)
• Carcinoma, Non-Small-Cell Lung (blood, metabolism)
• Carcinoma, Small Cell (blood, metabolism)
• Disease Progression
• Female
• Humans
• Immunoenzyme Techniques
• Interferon-gamma (biosynthesis)
• Interleukin-15 (metabolism, pharmacology)
• Interleukin-2 (metabolism, pharmacology)
• Interleukin-4 (biosynthesis)
• Interleukin-5 (biosynthesis)
• Leukocytes, Mononuclear (metabolism)
• Lung Neoplasms (blood, metabolism)
• Major Histocompatibility Complex
• Male
• Middle Aged
• Pleural Effusion (metabolism)
• Tumor Cells, Cultured