| Abstract | The present study explored the changes in hepatic secretion of tumour necrosis factor (TNF) and interleukin 6 (IL-6) during the regenerative process of the liver, focusing on the role of Kupffer cells. The secretions of TNF and IL-6 from the perfused rat liver were increased after 67% partial hepatectomy, reaching a maximum at 48 h. The response of cytokine secretion induced by lipopolysaccharide (LPS: 1 microgram/ml) was also potentiated in regenerating liver. The secretion of TNF, but not that of IL-6, induced by LPS was almost totally suppressed by pretreatment of rats with gadolinium chloride, which depletes Kupffer cells. These results indicate that hepatic secretions of TNF and IL-6 are increased during the regenerative process of the liver. Kupffer cells play an important role in hepatic secretion of TNF, whereas the production of IL-6 can be achieved by other cells of the liver. |
| Authors | M Iwai, T X Cui, H Kitamura, M Saito, T Shimazu
(Affiliation: Department of Medical Biochemistry, Ehime University School of Medicine, Shigenobu, Ehime, 791-0295, Japan. iwai at me1serv.m.ehime-u.ac.jp)
|
| Journal | Cytokine
(Cytokine)
Vol. 13
Issue 1
Pg. 60-64
(Jan 7 2001)
ISSN: 1043-4666 United States |
| PMID | 11145844
(Publication Type: In Vitro, Journal Article, Research Support, Non-U.S. Gov't)
|
| Copyright | Copyright 2001 Academic Press. |
| Chemical References |
- Interleukin-6
- Lipopolysaccharides
- Tumor Necrosis Factor-alpha
|
| Topics |
- Animals
- Hepatectomy
- Interleukin-6
(secretion)
- Lipopolysaccharides
(pharmacology)
- Liver
(drug effects, immunology, secretion)
- Liver Regeneration
(physiology)
- Male
- Perfusion
- Rats
- Rats, Sprague-Dawley
- Tumor Necrosis Factor-alpha
(secretion)
|
