[Immunity against diphtheria and tetanus in the adult Polish population].

Abstract

The aim of the study was to evaluate immunity against diphtheria and tetanus in healthy adult population in Poland. For determination of antitoxin IgG antibody, toxoid enzyme-linked immunosorbent assay (Toxoid-ELISA) was used. Serum samples were obtained from different regions of Poland and titrated for diphtheria (n = 2442) and tetanus (n = 827) IgG antitoxin. For calibration of anti-toxins determination, the WHO standard of human diphtheria and tetanus antitoxin was used. About 32% (n = 787) of persons were non-protected against diphtheria (IgG-DTAb < 0.1 IU/ml) and 24% (n = 195) against tetanus (IgG-TTAb < 0.1 IU/ml). In 63% (n = 1528) individuals basic protection for diphtheria and 48% (n = 402) for tetanus (0.1-1.0 IU/ml IgG-DTAb and IgG-TTAb) were observed. Only 5% (n = 127) were fully protected for diphtheria and 28% (n = 230) for tetanus (IgG-DTAb and IgG-TTAb > 1.0 IU/ml). In adults between 30-64 years of age, not vaccinated at least during last 10 years, 43% of persons were non-protected. The study showed insufficient immunity against diphtheria in adults. We indicate booster immunisation for selected group of persons.

• Authors: J Walory, P Grzesiowski, W Hryniewicz
• Journal: Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego (Pol Merkur Lekarski) Vol. 9 Issue 52 Pg. 687-92 (Oct 2000) ISSN: 1426-9686 [Print] Poland
• Vernacular Title: Stan uodpornienia przeciwko błonicy i tezcowi u dorosłych mieszkańców Polski.
• PMID: 11144058 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Diphtheria Toxoid
• Immunoglobulin G
• Tetanus Toxoid

Topics

• Adult
• Aged
• Diphtheria (immunology, prevention & control)
• Diphtheria Toxoid (administration & dosage, immunology)
• Enzyme-Linked Immunosorbent Assay
• Humans
• Immunoglobulin G (analysis)
• Middle Aged
• Poland (epidemiology)
• Reference Values
• Seroepidemiologic Studies
• Tetanus (immunology, prevention & control)
• Tetanus Toxoid (administration & dosage, immunology)