Two new acetylenic derivatives and a new meroditerpenoid from a Taiwanese marine sponge Strongylophora durissima.

Abstract

Further chemical examination of the sponge Strongylophora durissima yielded two new acetylenic derivatives, durissimols A (1) and B (2), and a new meroditerpenoid, strongylophorine-12 (5), in addition to the known acetylenic compounds, reneirin-2 (3), 18-hydroxyreneirin-2, melyne-C (4), duryne, siphanochalynol, and 24-ethylcholesterol (7). Among them, durissimol B (2) and duryne showed potent cytotoxicity against human gastric tumor (NUGC) cells.

• Authors: Y C Shen, C V Prakash
• Journal: Journal of natural products (J Nat Prod) Vol. 63 Issue 12 Pg. 1686-8 (Dec 2000) ISSN: 0163-3864 [Print] United States
• PMID: 11141118 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Alkynes
• Antineoplastic Agents
• Diterpenes
• durissimol A
• durissimol B
• strongylophorine-12
• Acetylene

Topics

• Acetylene (analogs & derivatives, chemistry, isolation & purification, pharmacology)
• Alkynes
• Animals
• Antineoplastic Agents (chemistry, isolation & purification, pharmacology)
• Diterpenes (chemistry, isolation & purification, pharmacology)
• Humans
• Molecular Structure
• Porifera (chemistry)
• Spectrum Analysis
• Tumor Cells, Cultured