HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

Efficacy of nitenpyram as a systemic flea adulticide in dogs and cats.

Abstract
In a clinical trial involving 123 cats and 88 dogs, the efficacy of tablets containing nitenpyram against natural flea infestations was investigated. The animals were selected from the routine cases of nine veterinary clinics in the UK and 143 were treated with the tablets and 68 control animals were treated with placebo tablets. Each animal was maintained in an individual cage. The time when the first fleas fell off each animal was recorded between 30 minutes and five hours after treatment, and six hours after treatment the numbers of live, moribund or dead fleas on each animal were determined, and the flea survival rate was calculated. The drug's efficacy was assessed by comparing the mean survival rates of fleas on the treated and control animals. Fleas started to fall from the animals 30 minutes after treatment and two hours after treatment some fleas had detached from 81 per cent of the treated animals. After six hours the efficacy of the drug reached 96.7 per cent on dogs and 95.2 per cent on cats, and 85.9 per cent of the fleas were found off the treated animals, compared with 1.8 per cent in the controls. No adverse drug reactions were recorded during the trial.
AuthorsP Dobson, O Tinembart, R D Fisch, P Junquera
JournalThe Veterinary record (Vet Rec) Vol. 147 Issue 25 Pg. 709-13 (Dec 16 2000) ISSN: 0042-4900 [Print] England
PMID11140929 (Publication Type: Clinical Trial, Journal Article, Multicenter Study, Randomized Controlled Trial)
Chemical References
  • Insecticides
  • Nicotine
Topics
  • Animals
  • Cat Diseases (drug therapy, parasitology)
  • Cats
  • Dog Diseases (drug therapy, parasitology)
  • Dogs
  • Female
  • Insecticides (chemistry, pharmacology)
  • Male
  • Nicotine (chemistry)
  • Plants
  • Siphonaptera
  • Treatment Outcome

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!


Choose Username:
Email:
Password:
Verify Password: