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A new C-nucleoside analogue of tiazofurin: synthesis and biological evaluation of 2-beta-D-ribofuranosylimidazole-4-carboxamide (imidazofurin).

Abstract
2-Beta-D-ribofuranosylimidazole-4-carboxamide, an imidazole analogue of the antitumor agent tiazofurin, was synthesized and evaluated for the growth inhibitory activity of human myelogenous leukemia K562 cells.
AuthorsP Franchetti, S Marchetti, L Cappellacci, J A Yalowitz, H N Jayaram, B M Goldstein, M Grifantini
JournalBioorganic & medicinal chemistry letters (Bioorg Med Chem Lett) Vol. 11 Issue 1 Pg. 67-9 (Jan 08 2001) ISSN: 0960-894X [Print] England
PMID11140736 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • 2-ribofuranosylimidazole-4-carboxamide
  • Antineoplastic Agents
  • Imidazoles
  • Monosaccharides
  • Ribavirin
  • IMP Dehydrogenase
  • tiazofurin
Topics
  • Antineoplastic Agents (chemical synthesis, chemistry, pharmacology)
  • Cell Division (drug effects)
  • Humans
  • IMP Dehydrogenase (antagonists & inhibitors)
  • Imidazoles (chemical synthesis, chemistry, pharmacology)
  • K562 Cells
  • Monosaccharides (chemical synthesis, pharmacology)
  • Ribavirin (analogs & derivatives, chemical synthesis, chemistry, pharmacology)

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