Abstract |
CD13 is commonly expressed in hematopoietic malignancies of myelomonocytic origin and has less commonly been described in lymphoid neoplasms, including acute lymphoblastic leukemia, B-cell lymphoproliferative disorders, and plasma cell malignancies. Aberrant CD13 expression has rarely been described in KP-1 (CD68)-positive large-cell lymphomas. However, CD13 positivity has not previously been described in a case of CD30+ (ALK-1+) anaplastic large-cell lymphoma of presumed null-cell origin without histiocytic differentiation. The purpose of this case report is to describe a CD30+ anaplastic large-cell lymphoma of presumed null-cell origin with aberrant expression of CD13. The case illustrates the unique usefulness of immunophenotypic and molecular techniques in establishing the correct diagnosis. The case was referred with a diagnosis of "rule out granulocytic sarcoma versus megakaryocytic malignancy" due to the morphology and a limited flow cytometric immunophenotypic (FCI) panel that had been performed and revealed expression of CD45, HLA-DR, and CD13. Subsequent morphologic review at our institution combined with an expanded FCI panel established the diagnosis. The differential diagnosis of a CD13+ hematopoietic malignancy should include this entity. The prognostic significance of this finding has yet to be determined.
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Authors | C H Dunphy, L J Gardner, J L Manes, C S Bee, K Taysi |
Journal | Journal of clinical laboratory analysis
(J Clin Lab Anal)
Vol. 14
Issue 6
Pg. 299-304
( 2000)
ISSN: 0887-8013 [Print] United States |
PMID | 11138613
(Publication Type: Case Reports, Journal Article, Review)
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Chemical References |
- HLA-DR Antigens
- Ki-1 Antigen
- Leukocyte Common Antigens
- CD13 Antigens
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Topics |
- Adolescent
- CD13 Antigens
(analysis)
- Cell Nucleolus
(pathology)
- Cell Nucleus
(pathology)
- Chromosome Aberrations
- Cytoplasm
(pathology)
- Flow Cytometry
- HLA-DR Antigens
(analysis)
- Humans
- Immunophenotyping
- Karyotyping
- Ki-1 Antigen
(analysis)
- Leukocyte Common Antigens
(analysis)
- Lymphoma, Large B-Cell, Diffuse
(genetics, immunology, pathology)
- Male
- Mitosis
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