Abstract |
Recently, 8-oxo-7,8-dihydrodeoxyguanosine triphosphatase (8-oxo-dGTPase; MTH1), a key enzyme for preventing oxidative stress-induced DNA damage, has been found to be expressed aberrantly in the nigrostriatal dopaminergic neurones in the brains of those with Parkinson's disease (PD). A valine (Val) to methionine (Met) polymorphism at codon 83 in exon 4 of the MTH1 gene was studied in 73 patients with sporadic PD and 151 age-matched non-PD controls by PCR-RFLP analysis, to determine a possible association of this polymorphism with development of PD. The frequency of either 83Val or 83Met allele was not statistically different between PD patients (92.5% or 7.5%) and the controls (88.7% or 11.3%) (chi(2) = 1.511, P = 0.2190). The 83Met/Met homozygotes consisting of an infrequent genotype in the control population (1.3%) were not found in the PD group. The frequency of both 83Val/Met heterozygotes and 83Met/Met homozygotes combined was not statistically different between PD patients (15.1%) and the controls (21.2%), compared with that of the 83Val/Val homozygotes (chi(2) = 1.190, P = 0.2754). These results indicate that the 83Val/Met polymorphism in the MTH1 gene is not associated with an increased risk for development of sporadic PD.
|
Authors | J Satoh, Y Kuroda |
Journal | European journal of neurology
(Eur J Neurol)
Vol. 7
Issue 6
Pg. 673-7
(Nov 2000)
ISSN: 1351-5101 [Print] England |
PMID | 11136354
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Methionine
- Phosphoric Monoester Hydrolases
- 8-oxodGTPase
- DNA Repair Enzymes
- Valine
|
Topics |
- Aged
- Aged, 80 and over
- Amino Acid Substitution
- DNA Repair Enzymes
- Exons
- Female
- Humans
- Male
- Methionine
- Middle Aged
- Parkinson Disease
(genetics)
- Phosphoric Monoester Hydrolases
(chemistry, genetics)
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Polymorphism, Restriction Fragment Length
- Reference Values
- Valine
|