| Abstract | OBJECTIVE: To identify clinical and genetic risk factors for extra-articular manifestations of rheumatoid arthritis (ExRA). METHODS: ExRA patients were identified retrospectively using predefined criteria in two hospital-based cohorts of RA patients, and compared to non-extraarticular RA controls from one of the cohorts, matched for disease duration. RESULTS: Forty-nine living and thirteen deceased cases of ExRA were identified. Extra-articular disease was predicted by the demonstration of antinuclear antibodies (Odds ratio (OR) 3.6; 95% CI: 1.4-9.1) and the presence of rheumatoid nodules within two years from RA diagnosis (OR 3.4; 95%, CI: 1.1-10.9) or at any time before ExRA onset (OR 2.8; 95% CI: 1.1-7.2). Male sex and rheumatoid factor did not affect the risk of ExRA. Although present in the majority of cases as well as controls, the disease associated HLA-DRB1 subtypes were not significant predictors of ExRA. CONCLUSION: Extra-articular manifestations of rheumatoid arthritis in a hospital based population were predicted by antinuclear antibodies and rheumatoid nodules. |
| Authors | C Turesson, L Jacobsson, U Bergström, L Truedsson, G Sturfelt
(Affiliation: Department of Rheumatology, Malmö University Hospital, Sweden. Carl.Turesson at telia.com)
|
| Journal | Scandinavian journal of rheumatology
(Scand J Rheumatol)
Vol. 29
Issue 6
Pg. 358-64
( 2000)
ISSN: 0300-9742 Norway |
| PMID | 11132204
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
| Chemical References |
- Antibodies, Antinuclear
- HLA-DR Antigens
- HLA-DRB1 antigen
|
| Topics |
- Adolescent
- Adult
- Antibodies, Antinuclear
(analysis)
- Arthritis, Rheumatoid
(complications, immunology)
- Child
- Cohort Studies
- Female
- HLA-DR Antigens
(analysis)
- Humans
- Male
- Middle Aged
- Prognosis
- Retrospective Studies
- Rheumatoid Nodule
(etiology)
|
