Abstract |
The effects of four recently discovered members of the Fibroblast Growth Factor family, FGF-10, FGF-16, FGF-17 and FGF-18, on the human embryonal carcinoma derived cell line Tera 2 were examined. It was found that all four FGF:s enhanced the survival rate of Tera-2 cells by counteracting apoptosis at concentrations in the interval 1-10 ng/ml. When higher concentrations of either of the four FGF:s were added, a preferential effect on cell motility was observed. The observed requirements for externally supplied FGF:s were complemented by the expression of all four FGF-receptors.
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Authors | M Granerus, W Engström |
Journal | Anticancer research
(Anticancer Res)
2000 Sep- Oct
Vol. 20
Issue 5B
Pg. 3527-31
ISSN: 0250-7005 [Print] Greece |
PMID | 11131657
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- FGF10 protein, human
- FGF17 protein, human
- Fgf16 protein, rat
- Fibroblast Growth Factor 10
- RNA, Messenger
- Receptors, Fibroblast Growth Factor
- Recombinant Proteins
- fibroblast growth factor 18
- Fibroblast Growth Factors
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Topics |
- Blotting, Northern
- Cell Division
(drug effects)
- Cell Movement
(drug effects)
- Dose-Response Relationship, Drug
- Fibroblast Growth Factor 10
- Fibroblast Growth Factors
(pharmacology)
- Humans
- RNA, Messenger
(biosynthesis, genetics)
- Receptors, Fibroblast Growth Factor
(biosynthesis, genetics)
- Recombinant Proteins
(pharmacology)
- Teratocarcinoma
(pathology)
- Tumor Cells, Cultured
(drug effects)
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