Dual effects of four members of the fibroblast growth factor member family on multiplication and motility in human teratocarcinoma cells in vitro.

Abstract

The effects of four recently discovered members of the Fibroblast Growth Factor family, FGF-10, FGF-16, FGF-17 and FGF-18, on the human embryonal carcinoma derived cell line Tera 2 were examined. It was found that all four FGF:s enhanced the survival rate of Tera-2 cells by counteracting apoptosis at concentrations in the interval 1-10 ng/ml. When higher concentrations of either of the four FGF:s were added, a preferential effect on cell motility was observed. The observed requirements for externally supplied FGF:s were complemented by the expression of all four FGF-receptors.

• Authors: M Granerus, W Engström
• Journal: Anticancer research (Anticancer Res) 2000 Sep- Oct Vol. 20 Issue 5B Pg. 3527-31 ISSN: 0250-7005 [Print] Greece
• PMID: 11131657 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• FGF10 protein, human
• FGF17 protein, human
• Fgf16 protein, rat
• Fibroblast Growth Factor 10
• RNA, Messenger
• Receptors, Fibroblast Growth Factor
• Recombinant Proteins
• fibroblast growth factor 18
• Fibroblast Growth Factors

Topics

• Blotting, Northern
• Cell Division (drug effects)
• Cell Movement (drug effects)
• Dose-Response Relationship, Drug
• Fibroblast Growth Factor 10
• Fibroblast Growth Factors (pharmacology)
• Humans
• RNA, Messenger (biosynthesis, genetics)
• Receptors, Fibroblast Growth Factor (biosynthesis, genetics)
• Recombinant Proteins (pharmacology)
• Teratocarcinoma (pathology)
• Tumor Cells, Cultured (drug effects)