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Reduction of vesicular acetylcholine transporter in beta-amyloid protein-infused rats with memory impairment.

Abstract
The aim of this study was to investigate spatial memory and quantitative acetylcholine transporter autoradiography using a high-sensitivity imaging plate system in rats treated with beta-amyloid protein, a model of Alzheimer's disease. An eight-arm radial maze was used to evaluate spatial memory. The performance of the eight-arm radial maze task was impaired in beta-amyloid protein-treated rats. In the parietal cortex, [3H]-vesamicol binding to the vesicular acetylcholine transporter was significantly lower in beta-amyloid protein-treated rats than in vehicle-treated rats, and was significantly correlated with the mean number of correct selections in the maze task of the first 5 days in the post-operative state. These results indicate that the reduction in [3H]-vesamicol binding to vesicular acetylcholine transporter is related to memory impairment induced by beta-amyloid protein. Beta-amyloid protein-infused rats with spatial memory impairment may be useful for the development of new radiolabelled vesamicol analogues for the objective evaluation of Alzheimer's disease.
AuthorsE Ikeda, K Shiba, H Mori, A Ichikawa, H Sumiya, I Kuji, N Tonami
JournalNuclear medicine communications (Nucl Med Commun) Vol. 21 Issue 10 Pg. 933-7 (Oct 2000) ISSN: 0143-3636 [Print] England
PMID11130334 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Amyloid beta-Peptides
  • Carrier Proteins
  • Membrane Transport Proteins
  • Piperidines
  • Radiopharmaceuticals
  • Receptors, Muscarinic
  • SLC18A3 protein, human
  • Slc18a3 protein, rat
  • Vesicular Acetylcholine Transport Proteins
  • Vesicular Transport Proteins
  • Tritium
  • vesamicol
  • Quinuclidinyl Benzilate
Topics
  • Alzheimer Disease (diagnostic imaging, metabolism)
  • Amyloid beta-Peptides (administration & dosage)
  • Animals
  • Autoradiography
  • Carrier Proteins (metabolism)
  • Disease Models, Animal
  • Humans
  • Immunohistochemistry
  • Male
  • Membrane Transport Proteins
  • Memory Disorders (chemically induced, diagnostic imaging, metabolism)
  • Piperidines (metabolism)
  • Quinuclidinyl Benzilate (metabolism)
  • Radionuclide Imaging
  • Radiopharmaceuticals
  • Rats
  • Rats, Sprague-Dawley
  • Receptors, Muscarinic (metabolism)
  • Synaptic Vesicles (metabolism)
  • Tissue Distribution
  • Tritium
  • Vesicular Acetylcholine Transport Proteins
  • Vesicular Transport Proteins

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