Transient splenic accumulation of Tc-99m HMDP caused by megaloblastic anemia.

Abstract

A case of transient splenic accumulation of the bone-seeking agent Tc-99m HMDP is reported. This effect was caused by transient megaloblastic anemia induced by 5-fluorouracil chemotherapy. The extent of splenic uptake reflected the development and severity of megaloblastic anemia. The mechanism of splenic accumulation is thought to be similar to transient iron deposition in the spleen by megaloblastic anemia.

• Authors: M Koizumi, T Suzuki, S Takahashi, E Ogata
• Journal: Clinical nuclear medicine (Clin Nucl Med) Vol. 25 Issue 12 Pg. 1024-7 (Dec 2000) ISSN: 0363-9762 [Print] United States
• PMID: 11129139 (Publication Type: Case Reports, Journal Article)

Chemical References

• Radiopharmaceuticals
• technetium Tc 99m hydroxymethylene diphosphonate
• Fluorouracil
• Technetium Tc 99m Medronate

Topics

• Anemia, Megaloblastic (chemically induced, complications)
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Bone Neoplasms (diagnostic imaging, secondary)
• Breast Neoplasms (pathology)
• Female
• Fluorouracil (administration & dosage, adverse effects)
• Humans
• Middle Aged
• Radionuclide Imaging
• Radiopharmaceuticals
• Spleen (diagnostic imaging)
• Technetium Tc 99m Medronate (analogs & derivatives)