[Immunophenotyping in acute leukemia: detection of minimal residual disease].

Abstract

Immunophenotyping improves both accuracy and reproducibility of the acute leukaemia classification and is considered particularly useful for identifying poorly differentiated subtypes of acute myeloid leukaemia and lineage association of acute lymphoid leukaemia. Immunological studies of leukaemic blasts has become critical also identifying biphenotypic leukaemias and acute myeloid leukaemia expressing lymphoid associated markers. At present, while the prognostic value of individual antigen expressions is still controversial, the immunologic detection of minimal residual disease seems to be important in monitoring the acute leukaemia patients in remission. In the present study immunophenotyping of bone marrow samples of 42 patients with acute myeloid leukaemia and 13 patients with acute lymphoid leukaemia was analysed. Patients were assessed both before and after treatment by immunophenotyping, cytogenetics and polymerase chain reaction amplification. The immunophenotyping have allowed more sensitive definition of acute leukaemia relapse, but molecular genetic methods are recommended for detection of elimination of residual disease.

• Authors: K Pálóczi, S Nahajevszky, K Jakab, N Regéczy, L Gopcsa, E László, J Földi
• Journal: Orvosi hetilap (Orv Hetil) Vol. 141 Issue 46 Pg. 2487-92 (Nov 12 2000) ISSN: 0030-6002 [Print] Hungary
• Vernacular Title: Immunfenotípus vizsgálata akut leukaemiákban: a minimális reziduális betegség kimutatási lehetósége.
• PMID: 11126681 (Publication Type: English Abstract, Journal Article)

Chemical References

• Antigens, CD
• Biomarkers, Tumor

Topics

• Adolescent
• Adult
• Aged
• Antigens, CD (metabolism)
• Biomarkers, Tumor (metabolism)
• Bone Marrow (metabolism)
• Female
• Flow Cytometry
• Humans
• Immunophenotyping
• Leukemia, Myeloid, Acute (diagnosis, genetics, immunology)
• Male
• Middle Aged
• Neoplasm, Residual (diagnosis)
• Precursor Cell Lymphoblastic Leukemia-Lymphoma (diagnosis, genetics, immunology)