In vitro and in vivo efficacies of T-3811ME (BMS-284756) against Mycoplasma pneumoniae.

Abstract

T-3811, the free base of T-3811ME (BMS-284756), a new des-F(6)-quinolone, showed a potent in vitro activity (MIC at which 90% of the isolates tested are inhibited [MIC(90)], 0.0313 microg/ml) against Mycoplasma pneumoniae. The MIC(90) of T-3811 was 4-fold higher than that of clarithromycin but was 4- to 8-fold lower than those of trovafloxacin, gatifloxacin, gemifloxacin, and moxifloxacin and was 16- to 32-fold lower than those of levofloxacin, ciprofloxacin, and minocycline. In an experimental M. pneumoniae pneumonia model in hamsters, after the administration of T-3811ME (20 mg/kg of body weight as T-3811, once daily, orally) for 5 days, the reduction of viable cells of M. pneumoniae in bronchoalveolar lavage fluid was greater than those of trovafloxacin, levofloxacin, and clarithromycin (20 and 40 mg/kg, orally) (P < 0.05).

• Authors: M Takahata, M Shimakura, R Hori, K Kizawa, Y Todo, S Minami, Y Watanabe, H Narita
• Journal: Antimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 45 Issue 1 Pg. 312-5 (Jan 2001) ISSN: 0066-4804 [Print] United States
• PMID: 11120986 (Publication Type: Journal Article)

Chemical References

• Anti-Infective Agents
• Fluoroquinolones
• Indoles
• Isoindoles
• Quinolones
• T 3811ME

Topics

• Animals
• Anti-Infective Agents (pharmacology, therapeutic use)
• Bronchoalveolar Lavage Fluid (microbiology)
• Cricetinae
• Fluoroquinolones
• Indoles (pharmacology, therapeutic use)
• Isoindoles
• Lung (microbiology)
• Male
• Mesocricetus
• Microbial Sensitivity Tests
• Mycoplasma pneumoniae (drug effects)
• Pneumonia, Mycoplasma (drug therapy, microbiology)
• Quinolones (pharmacology, therapeutic use)