In vivo activity of evernimicin (SCH 27899) against methicillin-resistant Staphylococcus aureus in experimental infective endocarditis.

Currently, there exist few satisfactory alternatives to vancomycin for therapy of serious methicillin-resistant Staphylococcus aureus (MRSA) infections. We employed a rat model of aortic valve endocarditis to assess the potential efficacy of evernimicin (SCH 27899) compared with vancomycin against infection with a strain susceptible to both agents (MICs of 0.25 and 0.50 microg/ml, respectively). Infected animals were assigned to one of three groups: controls (no treatment), evernimicin at 60 mg/kg of body weight by intravenous (i.v.) infusion once daily, or vancomycin at 150 mg/kg of body weight per day by continuous i.v. infusion. Therapy was administered for 5.5 days. At the start of therapy, colony counts in vegetations were 6.63 +/- 0.44 log(10) CFU/g. In both treatment groups, bacterial density within vegetations was significantly reduced in comparison with control animals that had not been treated. Final colony counts were as follows (mean +/- standard deviation): controls, 10.12 +/- 1.51 log(10) CFU/g of vegetation; evernimicin, 7.22 +/- 2.91 log(10) CFU/g of vegetation; vancomycin, 5.65 +/- 1.76 log(10) CFU/g of vegetation. The difference between the evernimicin and vancomycin groups was not significant. These results confirmed the bacteriostatic activity of evernimicin in vivo in an experimental model of severe MRSA infection.
AuthorsH W Boucher, C Thauvin-Eliopoulos, D Loebenberg, G M Eliopoulos
JournalAntimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 45 Issue 1 Pg. 208-11 (Jan 2001) ISSN: 0066-4804 [Print] UNITED STATES
PMID11120967 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Aminoglycosides
  • Anti-Bacterial Agents
  • evernimicin
  • Vancomycin
  • Aminoglycosides
  • Animals
  • Anti-Bacterial Agents (blood, therapeutic use)
  • Colony Count, Microbial
  • Endocarditis, Bacterial (drug therapy, microbiology)
  • Male
  • Methicillin Resistance
  • Rats
  • Rats, Sprague-Dawley
  • Staphylococcal Infections (drug therapy, microbiology)
  • Staphylococcus aureus (drug effects)
  • Treatment Outcome
  • Vancomycin (therapeutic use)

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