Supplemental systemic oxygen support using an intestinal intraluminal membrane oxygenator.

Abstract

An intraluminal membrane oxygenator (IMO) prototype was surgically inserted in the ileum and evaluated as a method of supporting systemic oxygenation in an acutely hypoxemic porcine model. Animals were assigned randomly to the test (n = 12) or the control (n = 8) groups, which underwent identical protocols with the exception of the O2 flow in the IMO device, which was shut off in the control group. In each case, hypoxia was induced by a reduction in the inspired oxygen fraction (FiO2) to 0.14. A highly significant improvement (p < 0.005) in arterial and venous O2 content and lower arteriovenous O2 difference (p < 0.05), cardiac output, and hemoglobin (p < 0.005) were found in the test group during hypoxia. The results show that it is possible to meet a physiologically significant portion of the body's O2 demands via the intestine during respiratory hypoxia and suggests that similar devices may be of significant potential value as a supplemental oxygenation device in cases of respiratory distress.

• Authors: B D Gross, E Sacristán, R A Peura, A Shahnarian, D Devereaux, H L Wang, R Fiddian-Green
• Journal: Artificial organs (Artif Organs) Vol. 24 Issue 11 Pg. 864-9 (Nov 2000) ISSN: 0160-564X [Print] United States
• PMID: 11119073 (Publication Type: Evaluation Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Hemoglobins
• Carbon Dioxide
• Oxygen

Topics

• Analysis of Variance
• Animals
• Carbon Dioxide (blood)
• Cardiac Output (physiology)
• Disease Models, Animal
• Equipment Design
• Feasibility Studies
• Female
• Hemoglobins (analysis)
• Hypoxia (blood, therapy)
• Ileum (blood supply, surgery)
• Male
• Mesenteric Artery, Superior (physiology)
• Mesenteric Veins (physiology)
• Oxygen (administration & dosage, blood)
• Oxygenators, Membrane
• Prostheses and Implants
• Random Allocation
• Regional Blood Flow (physiology)
• Respiratory Insufficiency (blood, therapy)
• Swine