WISH-PC2: a unique xenograft model of human prostatic small cell carcinoma.

Abstract

Prostatic small cell carcinoma is an aggressive subtype of prostate cancer that usually appears as a progression of the original adenocarcinoma. We describe here the WISH-PC2, a novel neuroendocrine xenograft of small cell carcinoma of the prostate. This xenograft was established from a poorly differentiated prostate adenocarcinoma and is serially transplanted in immune-compromised mice where it grows within the prostate, liver, and bone, inducing osteolytic lesions with foci of osteoblastic activity. It secretes to the mouse Chromogranin A and expresses prostate plasma carcinoma tumor antigen-1, six-transmembrane epithelial antigen of the prostate, and members of the Erb-B receptor family. It does not express prostate-specific antigen, prostate stem cell antigen, prostate-specific membrane antigen, and androgen receptor, and it grows independently of androgen. Altogether, WISH-PC2 provides an unlimited source in which to study the involvement of neuroendocrine cells in the progression of prostatic adenocarcinoma and can serve as a novel model for the testing of new therapeutic strategies for prostatic small cell carcinoma.

• Authors: J H Pinthus, T Waks, D G Schindler, A Harmelin, J W Said, A Belldegrun, J Ramon, Z Eshhar
• Journal: Cancer research (Cancer Res) Vol. 60 Issue 23 Pg. 6563-7 (Dec 01 2000) ISSN: 0008-5472 [Print] United States
• PMID: 11118033 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)

Topics

• Adenocarcinoma (pathology)
• Aged
• Animals
• Carcinoma, Small Cell (drug therapy, pathology)
• Cell Differentiation (physiology)
• Cell Division (physiology)
• Disease Models, Animal
• Humans
• Male
• Mice
• Mice, Inbred BALB C
• Mice, Inbred NOD
• Mice, SCID
• Phenotype
• Prostatic Neoplasms (drug therapy, pathology)
• Tumor Cells, Cultured
• Xenograft Model Antitumor Assays (methods)