Abstract | BACKGROUND: METHODS: Rats with two-kidney, one- clip (2K1C) hypertension with and without treatment with the angiotensin II type 1 receptor antagonist valsartan (3 mg/kg/day) were studied. In these animals as well as in spontaneously hypertensive rats (SHR), stroke-prone SHR (SHR-SP), hypertensive mRen-2 transgenic rats (TGR), and respective control strains, MCP-1 expression in the kidney was investigated by Northern and Western blots and by immunohistochemistry. Glomerular and interstitial MPhis were counted. RESULTS: In the nonclipped kidney of 2K1C rats, MCP-1 expression was elevated at 14 and 28 days when significant MPhi infiltration was present. MCP-1 was localized to glomerular endothelial and epithelial cells, interstitial and tubular cells, MPhis, and vascular smooth muscle cells. A similar pattern of MCP-1 staining was present in TGR kidneys, whereas MCP-1 expression was not increased in SHR and SHR-SP. Valsartan reduced but did not normalize blood pressure, blocked the induction of MCP-1 protein in 2K1C kidneys, and decreased interstitial MPhi infiltration significantly. CONCLUSION:
|
Authors | K F Hilgers, A Hartner, M Porst, M Mai, M Wittmann, C Hugo, D Ganten, H Geiger, R Veelken, J F Mann |
Journal | Kidney international
(Kidney Int)
Vol. 58
Issue 6
Pg. 2408-19
(Dec 2000)
ISSN: 0085-2538 [Print] United States |
PMID | 11115074
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Angiotensin Receptor Antagonists
- Antihypertensive Agents
- Chemokine CCL2
- RNA, Messenger
- Receptor, Angiotensin, Type 1
- Receptor, Angiotensin, Type 2
- Receptors, Angiotensin
- Tetrazoles
- Valsartan
- Valine
|
Topics |
- Angiotensin Receptor Antagonists
- Animals
- Antihypertensive Agents
(pharmacology)
- Blood Pressure
- Chemokine CCL2
(analysis, genetics)
- Chemotaxis, Leukocyte
(immunology)
- Gene Expression
(physiology)
- Hypertension, Renal
(drug therapy, immunology, pathology)
- Kidney
(chemistry, immunology, pathology)
- Kidney Failure, Chronic
(immunology)
- Macrophages
(cytology, immunology)
- Monocytes
(cytology, immunology)
- Nephrosclerosis
(drug therapy, immunology, pathology)
- RNA, Messenger
(analysis)
- Rats
- Rats, Inbred SHR
- Rats, Inbred WKY
- Rats, Mutant Strains
- Rats, Sprague-Dawley
- Receptor, Angiotensin, Type 1
- Receptor, Angiotensin, Type 2
- Receptors, Angiotensin
(physiology)
- Tetrazoles
(pharmacology)
- Valine
(analogs & derivatives, pharmacology)
- Valsartan
|
|
Join CureHunter, for free Research Interface BASIC access!
Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease.
Find out why thousands of doctors, pharma researchers and patient activists
around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!
|