HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

CD8(+) T cell-mediated skin disease in mice lacking IRF-2, the transcriptional attenuator of interferon-alpha/beta signaling.

Abstract
The balanced action of cytokines is known to be critical for the maintenance of homeostatic immune responses. Here, we report the development of an inflammatory skin disease involving CD8(+) T cells, in mice lacking the transcription factor, interferon regulatory factor-2 (IRF-2). CD8(+) T cells exhibit in vitro hyper-responsiveness to antigen stimulation, accompanied with a notable upregulation of the expression of genes induced by interferon-alpha/beta (IFN-alpha/beta). Furthermore, both disease development and CD8(+) T cell abnormality are suppressed by the introduction of nullizygosity to the genes that positively regulate the IFN-alpha/beta signaling pathway. IRF-2 may represent a unique negative regulator, attenuating IFN-alpha/beta-induced gene transcription, which is necessary for balancing the beneficial and harmful effects of IFN-alpha/beta signaling in the immune system.
AuthorsS Hida, K Ogasawara, K Sato, M Abe, H Takayanagi, T Yokochi, T Sato, S Hirose, T Shirai, S Taki, T Taniguchi
JournalImmunity (Immunity) Vol. 13 Issue 5 Pg. 643-55 (Nov 2000) ISSN: 1074-7613 [Print] United States
PMID11114377 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • DNA-Binding Proteins
  • Interferon Regulatory Factor-2
  • Irf2 protein, mouse
  • Repressor Proteins
  • Transcription Factors
  • Interferons
Topics
  • Animals
  • CD8-Positive T-Lymphocytes (immunology)
  • Cytotoxicity, Immunologic
  • DNA-Binding Proteins (genetics, immunology)
  • Gene Expression Regulation (immunology)
  • Interferon Regulatory Factor-2
  • Interferons (genetics, immunology)
  • Mice
  • Mice, Knockout
  • Repressor Proteins
  • Signal Transduction (genetics, immunology)
  • Skin Diseases (etiology, genetics, immunology)
  • Transcription Factors (genetics, immunology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: