| Abstract | Urinary endothelin (ET)-1 excretion is present in non-insulin dependent diabetes (NIDDM) patients with microalbuminuria, and an increase in circulating ET-1 precedes the microalbuminuric phase of renal injury related to diabetes. The aim of the present study was to determine whether various drugs alter urinary ET-1 levels and urinary albumin excretion (UAE) in NIDDM patients with microalbuminuria. Forty-five NIDDM patients with microalbuminuria were randomly assigned to three groups: those treated with pioglitazone at 30 mg/day (n=15), those treated with glibenclamide at 5 mg/day (n=15), and those treated with voglibose at 0.6 mg/day (n=15). Patients received these drugs for 3 months. UAE, urinary ET-1, and plasma ET-1 levels were measured in these patients before and after treatment. Before treatment, UAE, urinary ET-1, and plasma ET-1 levels differed little among the three groups. UAE in the 45 NIDDM patients (156.2+/-42.8 microg/min) was greater than that in 30 healthy controls (8.2+/-2.6 microg/min) (P<.001). Urinary ET-1 levels in the NIDDM patients (8.7+/-1.3 ng/g urinary creatinine (UC)) were significantly higher than that in the controls (2.4+/-0.2 ng/g UC) (P<.01). Plasma ET-1 levels, however, in the NIDDM patients (1.3+/-0.4 pg/ml) did not differ significantly from the levels in healthy controls (1.0+/-0.6 pg/ml). Pioglitazone but no glibenclamide or voglibose reduced UAE from 142.8+/-42.2 to 48. 4+/-18.2 microg/min (P<.01) and urinary ET-1 levels from 8.6+/-1.3 to 3.4+/-0.5 ng/g UC (P<.01). These data suggest pioglitazone to be effective in reducing UAE and urinary ET-1 concentrations in NIDDM patients with microalbuminuria. |
| Authors | T Nakamura, C Ushiyama, N Shimada, K Hayashi, I Ebihara, H Koide
(Affiliation: Department of Medicine, Misato Junshin Hospital, 745 Kobo, Saitama, Misato, Japan.)
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| Journal | Journal of diabetes and its complications
(J Diabetes Complications)
2000 Sep-Oct
Vol. 14
Issue 5
Pg. 250-4
ISSN: 1056-8727 UNITED STATES |
| PMID | 11113686
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Multicenter Study, Randomized Controlled Trial)
|
| Chemical References |
- Endothelin-1
- Enzyme Inhibitors
- Hemoglobin A, Glycosylated
- Hypoglycemic Agents
- Thiazoles
- Thiazolidinediones
- Glyburide
- pioglitazone
- Inositol
- voglibose
|
| Topics |
- Albuminuria
- Blood Pressure
(drug effects)
- Diabetes Mellitus, Type 2
(drug therapy, physiopathology, urine)
- Endothelin-1
(urine)
- Enzyme Inhibitors
(pharmacology, therapeutic use)
- Female
- Glyburide
(pharmacology, therapeutic use)
- Hemoglobin A, Glycosylated
(metabolism)
- Humans
- Hypoglycemic Agents
(pharmacology, therapeutic use)
- Inositol
(analogs & derivatives, pharmacology, therapeutic use)
- Male
- Middle Aged
- Reference Values
- Thiazoles
(pharmacology, therapeutic use)
- Thiazolidinediones
|
