The effect of antibacterial soap with 1.5% triclocarban on Staphylococcus aureus in patients with atopic dermatitis.

Abstract

This double-blind study determined whether daily bathing with an antibacterial soap would reduce the number of Staphylococcus aureus on the skin and result in clinical improvement of atopic dermatitis. For 9 weeks, 50 patients with moderately severe atopic dermatitis bathed daily with either an antimicrobial soap containing 1.5% triclocarban or the placebo soap. They also used a nonmedicated moisturizer and 0.025% triamcinolone acetonide cream as needed, but the availability of the corticosteroid cream was discontinued after 6 weeks. The antimicrobial soap regimen caused significantly greater improvement in the severity and extent of skin lesions than the placebo soap regimen, which correlated with reductions both in S aureus in patients with positive cultures at baseline and in total aerobic organisms. Outcome measures included reductions in S aureus, total aerobic organisms, and dermatologic assessments. Overall, daily bathing with an antibacterial soap was well tolerated, provided clinical improvement, and reduced levels of skin microorganisms.

• Authors: D L Breneman, J M Hanifin, C A Berge, B H Keswick, P B Neumann
• Journal: Cutis (Cutis) Vol. 66 Issue 4 Pg. 296-300 (Oct 2000) ISSN: 0011-4162 [Print] United States
• PMID: 11109156 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Infective Agents, Local
• Carbanilides
• triclocarban

Topics

• Adolescent
• Adult
• Aged
• Analysis of Variance
• Anti-Infective Agents, Local (administration & dosage)
• Baths
• Carbanilides (administration & dosage)
• Child
• Dermatitis, Atopic (microbiology)
• Double-Blind Method
• Female
• Humans
• Male
• Middle Aged
• Staphylococcal Skin Infections (drug therapy)
• Staphylococcus aureus (drug effects, isolation & purification)