Abstract | BACKGROUND AND AIMS: METHODS: RESULTS: We studied 12 patients with BCS who were seen between April 1968 and February 1999. All of them had MOVC. Hepatocellular carcinoma developed in three (25%) of them. There were no obvious differences in the clinical features and imaging findings concerning MOVC between patients with and without HCC. Hepatocellular carcinoma in these three patients showed no clear trend in clinical features and imaging findings. Of the hepatitis viral markers examined, HBsAg, anti-HBc and HBV- DNA were positive in only one of three patients with HCC and all of the viral markers were negative in the other two patients. CONCLUSIONS: Chronic congestion in the liver, caused by an outflow block of hepatic veins and subsequent histopathologic change, must have led to HCC in two patients without any hepatitis viral markers. Patients with MOVC should be followed closely as a high-risk group for HCC.
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Authors | S Matsui, T Ichida, M Watanabe, S Sugitani, T Suda, T Takahashi, H Asakura |
Journal | Journal of gastroenterology and hepatology
(J Gastroenterol Hepatol)
Vol. 15
Issue 10
Pg. 1205-11
(Oct 2000)
ISSN: 0815-9319 [Print] Australia |
PMID | 11106103
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Biomarkers
- Biomarkers, Tumor
- DNA, Viral
- Hepatitis B Antibodies
- Hepatitis B Surface Antigens
- Hepatitis C Antibodies
- Protein Precursors
- RNA, Viral
- alpha-Fetoproteins
- acarboxyprothrombin
- Prothrombin
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Topics |
- Adult
- Aged
- Biomarkers
- Biomarkers, Tumor
- Blotting, Southern
- Budd-Chiari Syndrome
(complications)
- Carcinoma, Hepatocellular
(diagnosis, etiology, pathology)
- DNA, Viral
(analysis)
- Female
- Flaviviridae
(genetics, immunology)
- Hepacivirus
(genetics)
- Hepatitis B Antibodies
(analysis)
- Hepatitis B Surface Antigens
(analysis)
- Hepatitis B virus
(genetics)
- Hepatitis C Antibodies
(analysis)
- Hepatitis, Viral, Human
(complications, diagnosis, immunology)
- Humans
- Immunoenzyme Techniques
- Liver
(pathology)
- Liver Neoplasms
(diagnosis, etiology, pathology)
- Magnetic Resonance Imaging
- Male
- Middle Aged
- Protein Precursors
(blood)
- Prothrombin
(metabolism)
- RNA, Viral
(analysis)
- Reverse Transcriptase Polymerase Chain Reaction
- Tomography, X-Ray Computed
- Vena Cava, Inferior
- Venous Thrombosis
(complications)
- alpha-Fetoproteins
(analysis)
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