Abstract | RATIONALE: OBJECTIVE: METHODS: Each rat was prepared with an indwelling jugular catheter and trained to self-administer intravenous nicotine (0.03 mg/kg per infusion). After nicotine self-administration stabilized, rats were pretreated with either (-)- nicotine (0, 0.1, 0.3, and 1.0 mg/kg free base) or (+/-)- nornicotine (0, 1, 3, 5.6, and 10.0 mg/kg free base) and assessed for nicotine self-administration. A separate group of rats was maintained on sucrose reinforced responding and pretreated with nornicotine to determine the specificity of the pretreatment effect. In another group of rats, the time course of the pretreatment effect of either (-)- nicotine (0.56 and 1.0 mg/kg) or (+/-)- nornicotine (5.6 and 10.0 mg/kg) was examined. RESULTS: CONCLUSION:
|
Authors | T A Green, S B Phillips, P A Crooks, L P Dwoskin, M T Bardo |
Journal | Psychopharmacology
(Psychopharmacology (Berl))
Vol. 152
Issue 3
Pg. 289-94
(Oct 2000)
ISSN: 0033-3158 [Print] Germany |
PMID | 11105939
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
|
Chemical References |
|
Topics |
- Animals
- Dose-Response Relationship, Drug
- Male
- Nicotine
(administration & dosage, analogs & derivatives, pharmacology)
- Rats
- Rats, Sprague-Dawley
- Self Administration
|