A soluble form of B cell maturation antigen, a receptor for the tumor necrosis factor family member APRIL, inhibits tumor cell growth.

Abstract	A proliferation-inducing ligand (APRIL) is a ligand of the tumor necrosis factor (TNF) family that stimulates tumor cell growth in vitro and in vivo. Expression of APRIL is highly upregulated in many tumors including colon and prostate carcinomas. Here we identify B cell maturation antigen (BCMA) and transmembrane activator and calcium modulator and cyclophilin ligand (CAML) interactor (TACI), two predicted members of the TNF receptor family, as receptors for APRIL. APRIL binds BCMA with higher affinity than TACI. A soluble form of BCMA, which inhibits the proliferative activity of APRIL in vitro, decreases tumor cell proliferation in nude mice. Growth of HT29 colon carcinoma cells is blocked when mice are treated once per week with the soluble receptor. These results suggest an important role for APRIL in tumorigenesis and point towards a novel anticancer strategy.
Authors	P Rennert, P Schneider, T G Cachero, J Thompson, L Trabach, S Hertig, N Holler, F Qian, C Mullen, K Strauch, J L Browning, C Ambrose, J Tschopp
Journal	The Journal of experimental medicine (J Exp Med) Vol. 192 Issue 11 Pg. 1677-84 (Dec 04 2000) ISSN: 0022-1007 [Print] United States
PMID	11104810 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Adaptor Proteins, Signal Transducing B-Cell Activating Factor B-Cell Maturation Antigen CAMLG protein, human Caml protein, mouse Carrier Proteins Membrane Proteins Receptors, Tumor Necrosis Factor Recombinant Fusion Proteins TNFRSF13B protein, human TNFRSF17 protein, human TNFSF13 protein, human TNFSF13B protein, human Tnfrsf13b protein, mouse Tnfrsf17 protein, mouse Tnfsf13 protein, mouse Tnfsf13b protein, mouse Transmembrane Activator and CAML Interactor Protein Tumor Necrosis Factor Ligand Superfamily Member 13 Tumor Necrosis Factor-alpha
Topics	3T3 Cells Adaptor Proteins, Signal Transducing Animals B-Cell Activating Factor B-Cell Maturation Antigen B-Lymphocytes (physiology) Carrier Proteins (metabolism) Cell Division Cell Line, Transformed Cell Transformation, Neoplastic HT29 Cells Humans Membrane Proteins (genetics, metabolism) Mice Mice, Nude Neoplasms (therapy) Receptors, Tumor Necrosis Factor (genetics, metabolism) Recombinant Fusion Proteins (genetics, metabolism) Solubility Transmembrane Activator and CAML Interactor Protein Tumor Cells, Cultured Tumor Necrosis Factor Ligand Superfamily Member 13 Tumor Necrosis Factor-alpha (genetics, metabolism)

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