Abstract | BACKGROUND: METHODS: Sixty patients with AMI who underwent reperfusion therapy were randomly assigned to an imidapril group (20 patients), a bisoprolol group (20 patients), or a control group (20 patients). Administration was started within 24 hours. Left ventricular function on admission and 3 months and 1 year after AMI was investigated. RESULTS: Baseline characteristics on admission were similar in the 3 groups except for sex distribution. Mean pulmonary capillary wedge pressure and left ventricular end-diastolic pressure in the bisoprolol group were higher than those in the imidapril group 1 year after admission (pulmonary capillary wedge pressure: 12 +/- 7 vs 8 +/- 2 mm Hg, left ventricular end-diastolic pressure: 17 +/- 8 vs 11 +/- 4 mm Hg, P <. 01). Left ventricular end-diastolic volume index (EDVI) increased in the bisoprolol group throughout the 1-year period (P <.01), whereas EDVI in the imidapril group decreased (P <.01). The increases in EDVI during 1 year in the bisoprolol group were greater than those of the other 2 groups ( bisoprolol: 12 +/- 10, imidapril: -9 +/- 7, control: 4 +/- 11 mL/m2, P <.01). CONCLUSIONS:
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Authors | Y Yoshitomi, S Kojima, M Yano, T Sugi, Y Matsumoto, M Kuramochi |
Journal | American heart journal
(Am Heart J)
Vol. 140
Issue 6
Pg. E27
(Dec 2000)
ISSN: 0002-8703 [Print] United States |
PMID | 11100000
(Publication Type: Journal Article, Randomized Controlled Trial)
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Chemical References |
- Adrenergic beta-Antagonists
- Angiotensin-Converting Enzyme Inhibitors
- Imidazolidines
- imidapril
- Bisoprolol
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Topics |
- Adrenergic beta-Antagonists
(therapeutic use)
- Adult
- Aged
- Aged, 80 and over
- Angiotensin-Converting Enzyme Inhibitors
(therapeutic use)
- Bisoprolol
(therapeutic use)
- Coronary Angiography
- Coronary Circulation
- Female
- Heart Ventricles
(diagnostic imaging)
- Hemodynamics
- Humans
- Imidazolidines
(therapeutic use)
- Longitudinal Studies
- Male
- Middle Aged
- Myocardial Infarction
(diagnostic imaging, drug therapy, therapy)
- Myocardial Reperfusion
- Vascular Patency
- Ventricular Remodeling
(drug effects)
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