Pathogenesis and treatment of inflammatory demyelinating polyradiculoneuropathy.

Abstract

Inflammatory demyelinating polyradiculoneuropathy causes a spectrum of conditions ranging from acute (Guillain-Barré syndrome), through subacute to chronic forms. The pathogenesis of acute forms is related to antibody responses against glycolipid epitopes which mimic bacterial, especially Campylobacter jejuni, structures but T cells are also involved. The pathogenesis of chronic forms is poorly understood. Different forms differ in their responses to steroids. Chronic inflammatory demyelinating polyradiculoneuropathy responds to steroids but a variant multifocal motor neuropathy and the acute forms of inflammatory demyelinating polyradiculoneuropathy do not. Acute and chronic forms respond to plasma exchange and intravenous immunoglobulin.

• Authors: R A Hughes
• Journal: Acta neurologica Belgica (Acta Neurol Belg) Vol. 100 Issue 3 Pg. 167-70 (Sep 2000) ISSN: 0300-9009 [Print] Italy
• PMID: 11098290 (Publication Type: Journal Article, Review)

Chemical References

• Gangliosides

Topics

• Gangliosides (immunology)
• Humans
• Immunotherapy (methods)
• Plasma Exchange
• Polyradiculoneuropathy, Chronic Inflammatory Demyelinating (immunology, pathology, therapy)