Abstract |
Continuous intravenous infusion of low doses of insulin has been successfully used since 1972 in the treatment of " diabetic coma". The achieved levels of plasma insulin satisfy the transport of glucose and the inhibition of lipolysis. We are to report upon 8 children (mean age: 8.5 years), 6 with diabetic ketoacidosis and 2 with hyperosmolar diabetic coma. Blood sugar levels of 300 mg/dl or less were reached after averagely 8 hours of therapy and an average consumption of 0.8 U insulin/kg. Sodium and potassium levels, osmolality and acid base parameters for the first 24 hours are described. Low-dose continuous intravenous insulin infusion was effective, simple and safe in all cases. The presently recommended dosage of 0.1 insulin/kg x hour is to be used flexibly (range: 0.05--0.2 U/kg x hour). The administration of bicarbonate should be cautiously used for patients with severe acidosis. Infusion of hypotonic solutions as part of the treatment of the hyperosmolar diabetic coma can be dangerous. A new therapeutic regime based on our results is proposed.
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Authors | M Frank, H Hörnchen, R Joosten |
Journal | Klinische Padiatrie
(Klin Padiatr)
Vol. 191
Issue 3
Pg. 271-9
(May 1979)
ISSN: 0300-8630 [Print] Germany |
Vernacular Title | Diabetische Ketoazidose und Coma diabeticum hyperosmolare im Kindesalter. Behandlung mit kontinuierlicher Infusion kleiner Insulindosen. |
PMID | 110975
(Publication Type: English Abstract, Journal Article)
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Chemical References |
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Topics |
- Adolescent
- Child
- Diabetic Coma
(drug therapy)
- Diabetic Ketoacidosis
(drug therapy)
- Female
- Humans
- Infant
- Infusions, Parenteral
- Insulin
(administration & dosage)
- Male
- Osmolar Concentration
- Potassium
(blood)
- Sodium
(blood)
- Time Factors
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