Abstract | BACKGROUND: METHODS: We analyzed 30 patients who were discovered to have brain metastases during the diagnosis of 121 patients enrolled in three consecutive clinical trials on advanced NSCLC assessing combination chemotherapy of cisplatin, ifosfamide and irinotecan with rhG-CSF support. Response in the brain lesions was evaluated by contrast-enhanced MRI scans after at least two courses. RESULTS: Fourteen patients achieved a partial response (PR) but there was no change (NC) in 13 patients and progressive disease (PD) in 1. Among patients with extracranial lesions, 18 had a PR and 11 had NC. The response rate in brain metastases was 50.0%, and that in extracranial primary and metastatic lesions was 62.1%. The median duration of response for intra- and extracranial lesions was 140 and 147 days, respectively. After completing chemotherapy, Gamma Knife radiosurgery was performed on 2 patients in remission and 8 patients at disease progression. The median survival time and 1-year survival rate were 382 days and 56.1%, respectively. CONCLUSIONS:
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Authors | A Fujita, S Fukuoka, H Takabatake, S Tagaki, K Sekine |
Journal | Oncology
(Oncology)
Vol. 59
Issue 4
Pg. 291-5
(Nov 2000)
ISSN: 0030-2414 [Print] Switzerland |
PMID | 11096340
(Publication Type: Journal Article)
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Copyright | Copyright 2000 S. Karger AG, Basel. |
Chemical References |
- Recombinant Proteins
- Granulocyte Colony-Stimulating Factor
- Irinotecan
- Cisplatin
- Ifosfamide
- Camptothecin
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Topics |
- Adult
- Aged
- Antineoplastic Combined Chemotherapy Protocols
(adverse effects, therapeutic use)
- Brain Neoplasms
(drug therapy, radiotherapy, secondary, surgery)
- Camptothecin
(administration & dosage, analogs & derivatives)
- Carcinoma, Small Cell
(drug therapy, radiotherapy, secondary, surgery)
- Chemotherapy, Adjuvant
- Cisplatin
(administration & dosage)
- Female
- Granulocyte Colony-Stimulating Factor
(therapeutic use)
- Humans
- Ifosfamide
(administration & dosage)
- Irinotecan
- Lung Neoplasms
(pathology)
- Male
- Middle Aged
- Radiosurgery
- Radiotherapy, Adjuvant
- Recombinant Proteins
- Retrospective Studies
- Survival Analysis
- Treatment Outcome
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