Heat shock protein 47 in renal scarring.

Abstract

Heat shock protein 47 (HSP47) is a collagen-binding protein, thought to play an essential mechanistic role in the assembly and processing of procollagens. HSP47 is increasingly being implicated in the pathogenesis of several human and experimental fibrotic diseases. HSP47 could mediate increased accumulation of collagens in the fibrotic mass, possibly by regulating increased assembly of procollagens. Therefore, modulation of HSP47 might be a valuable tool for manipulation of some fibrotic diseases, including renal scarring

• Authors: M S Razzaque, N Ahsan, T Taguchi
• Journal: Nephron (Nephron) Vol. 86 Issue 3 Pg. 339-41 (Nov 2000) ISSN: 1660-8151 [Print] Switzerland
• PMID: 11096292 (Publication Type: Journal Article, Review)
• Copyright: Copyright 2000 S. Karger AG, Basel

Chemical References

• HSP47 Heat-Shock Proteins
• Heat-Shock Proteins
• SERPINH1 protein, human
• Collagen

Topics

• Cicatrix (metabolism, pathology)
• Collagen (metabolism)
• Fibrosis
• HSP47 Heat-Shock Proteins
• Heat-Shock Proteins (metabolism)
• Humans
• Kidney Diseases (metabolism, pathology)