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Anti-inflammatory effects of a stabilized lipid extract of Perna canaliculus (Lyprinol).

Abstract
A lipid-rich extract, prepared by supercritical fluid (CO2) extraction of freeze-dried stabilized NZ green-lipped mussel powder (Lyprinol) has shown significant anti-inflammatory (AI) activity when given to animals and humans. When treated p.o. with Lyprinol, Wistar and Dark Agouti rats developed neither adjuvant-induced polyarthritis or collagen(II)-induced auto-allergic arthritis. This was achieved with doses < NSAIDs, and 200 times < of other seed or fish oils. Lyprinol subfractions inhibited LTB4 biosynthesis by PMN in vitro, and PGE2 production by activated macrophages. Much of this AI activity was associated with omega-3 PUFAs and natural antioxidants [e.g. carotenoids]. In contrast to NSAIDs, Lyprinol is non-gastro toxic in disease-stressed rats at 300 mg/kg p.o., and does not affect platelet aggregation [human, rat]. Clinical studies, either controlled or randomized, have demonstrated very significant AI activity in patients with osteoarthritis (OA), rheumatoid arthritis (RA), asthma, and other inflammatory conditions. Lyprinol is a reproducible, stable source of bioactive lipids with much greater potency than plant/marine oils currently used as nutritional supplements to ameliorate signs of inflammation.
AuthorsG M Halpern
JournalAllergie et immunologie (Allerg Immunol (Paris)) Vol. 32 Issue 7 Pg. 272-8 (Sep 2000) ISSN: 0397-9148 [Print] France
PMID11094640 (Publication Type: Comparative Study, Journal Article, Review)
Chemical References
  • Anti-Asthmatic Agents
  • Anti-Inflammatory Agents, Non-Steroidal
  • Hydroxyeicosatetraenoic Acids
  • Leukotrienes
  • Lipids
  • Lipoxygenase Inhibitors
  • Plant Oils
  • Preservatives, Pharmaceutical
  • Tartrates
  • Tissue Extracts
  • lyprinol
  • 5-hydroxy-6,8,11,14-eicosatetraenoic acid
  • tartaric acid
Topics
  • Animals
  • Anti-Asthmatic Agents (administration & dosage, isolation & purification, pharmacology, therapeutic use)
  • Anti-Inflammatory Agents, Non-Steroidal (administration & dosage, isolation & purification, pharmacology, therapeutic use)
  • Arthritis, Experimental (drug therapy)
  • Arthritis, Rheumatoid (drug therapy)
  • Asthma (drug therapy)
  • Bivalvia (chemistry)
  • Clinical Trials as Topic
  • Double-Blind Method
  • Drug Administration Routes
  • Drug Evaluation, Preclinical
  • Drug Stability
  • Freeze Drying
  • Humans
  • Hydroxyeicosatetraenoic Acids (biosynthesis)
  • Leukotrienes (biosynthesis)
  • Lipids (administration & dosage, isolation & purification, pharmacology, therapeutic use)
  • Lipoxygenase Inhibitors (administration & dosage, isolation & purification, pharmacology, therapeutic use)
  • Medicine, Traditional
  • Neutrophils (drug effects, metabolism)
  • New Zealand
  • Osteoarthritis (drug therapy)
  • Plant Oils (pharmacology, therapeutic use)
  • Preservatives, Pharmaceutical (pharmacology)
  • Randomized Controlled Trials as Topic
  • Rats
  • Rats, Wistar
  • Tartrates (pharmacology)
  • Tissue Extracts (chemistry)
  • Treatment Outcome

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