Abstract |
A lipid-rich extract, prepared by supercritical fluid (CO2) extraction of freeze-dried stabilized NZ green-lipped mussel powder ( Lyprinol) has shown significant anti-inflammatory (AI) activity when given to animals and humans. When treated p.o. with Lyprinol, Wistar and Dark Agouti rats developed neither adjuvant-induced polyarthritis or collagen(II)-induced auto-allergic arthritis. This was achieved with doses < NSAIDs, and 200 times < of other seed or fish oils. Lyprinol subfractions inhibited LTB4 biosynthesis by PMN in vitro, and PGE2 production by activated macrophages. Much of this AI activity was associated with omega-3 PUFAs and natural antioxidants [e.g. carotenoids]. In contrast to NSAIDs, Lyprinol is non-gastro toxic in disease-stressed rats at 300 mg/kg p.o., and does not affect platelet aggregation [human, rat]. Clinical studies, either controlled or randomized, have demonstrated very significant AI activity in patients with osteoarthritis (OA), rheumatoid arthritis (RA), asthma, and other inflammatory conditions. Lyprinol is a reproducible, stable source of bioactive lipids with much greater potency than plant/marine oils currently used as nutritional supplements to ameliorate signs of inflammation.
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Authors | G M Halpern |
Journal | Allergie et immunologie
(Allerg Immunol (Paris))
Vol. 32
Issue 7
Pg. 272-8
(Sep 2000)
ISSN: 0397-9148 [Print] France |
PMID | 11094640
(Publication Type: Comparative Study, Journal Article, Review)
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Chemical References |
- Anti-Asthmatic Agents
- Anti-Inflammatory Agents, Non-Steroidal
- Hydroxyeicosatetraenoic Acids
- Leukotrienes
- Lipids
- Lipoxygenase Inhibitors
- Plant Oils
- Preservatives, Pharmaceutical
- Tartrates
- Tissue Extracts
- lyprinol
- 5-hydroxy-6,8,11,14-eicosatetraenoic acid
- tartaric acid
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Topics |
- Animals
- Anti-Asthmatic Agents
(administration & dosage, isolation & purification, pharmacology, therapeutic use)
- Anti-Inflammatory Agents, Non-Steroidal
(administration & dosage, isolation & purification, pharmacology, therapeutic use)
- Arthritis, Experimental
(drug therapy)
- Arthritis, Rheumatoid
(drug therapy)
- Asthma
(drug therapy)
- Bivalvia
(chemistry)
- Clinical Trials as Topic
- Double-Blind Method
- Drug Administration Routes
- Drug Evaluation, Preclinical
- Drug Stability
- Freeze Drying
- Humans
- Hydroxyeicosatetraenoic Acids
(biosynthesis)
- Leukotrienes
(biosynthesis)
- Lipids
(administration & dosage, isolation & purification, pharmacology, therapeutic use)
- Lipoxygenase Inhibitors
(administration & dosage, isolation & purification, pharmacology, therapeutic use)
- Medicine, Traditional
- Neutrophils
(drug effects, metabolism)
- New Zealand
- Osteoarthritis
(drug therapy)
- Plant Oils
(pharmacology, therapeutic use)
- Preservatives, Pharmaceutical
(pharmacology)
- Randomized Controlled Trials as Topic
- Rats
- Rats, Wistar
- Tartrates
(pharmacology)
- Tissue Extracts
(chemistry)
- Treatment Outcome
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