Abstract |
Inherited susceptibility to rheumatoid arthritis (RA) is associated with the DRB1 genes encoding the human leukocyte antigen (HLA)-DR4 and HLA-DR1 molecules. Transgenic mice expressing these major histocompatibility complex ( MHC) class II molecules have been developed to generate humanized models for RA. The relevance of these models for understanding RA will be discussed.
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Authors | L Fugger, A Svejgaard |
Journal | Arthritis research
(Arthritis Res)
Vol. 2
Issue 3
Pg. 208-11
( 2000)
ISSN: 1465-9905 [Print] England |
PMID | 11094431
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
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Chemical References |
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Topics |
- Animals
- Arthritis, Rheumatoid
(immunology)
- Disease Models, Animal
- HLA-DR4 Antigen
(genetics, immunology)
- Humans
- Mice
- Mice, Transgenic
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