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Synthesis of galactosyl and lactosyl derivatives as potential anti-metastasis compounds.

Abstract
Based on the known anti-metastasis activities of lactosides and galactosides, a galactosyl and a lactosyl trimannoside were prepared via the conventional Koenigs-Knorr and trichloroacetimidate methods, respectively. Through typical deblocking procedures, a tetrasaccharide alpha-D-Galp-(1 --> 2)-alpha-D-Manp-(1 --> 2)-alpha-D-Manp-(1 --> 6)-alpha-D-ManpOCH3 and a pentasaccharide beta-D-Galp-(1 --> 4)-beta-D-Glcp-(1 --> 2)-alpha-D-Manp-(1 --> 2)-alpha-D-Manp-(1 --> 6)-alpha-D-ManpOCH3 were obtained.
AuthorsH Li, Q Li, M S Cai, Z J Li
JournalCarbohydrate research (Carbohydr Res) Vol. 328 Issue 4 Pg. 611-5 (Oct 06 2000) ISSN: 0008-6215 [Print] Netherlands
PMID11093718 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antineoplastic Agents
  • Galactosides
  • Glycosides
  • Mannosides
  • Oligosaccharides
  • lactosides
Topics
  • Antineoplastic Agents (chemical synthesis)
  • Carbohydrate Conformation
  • Carbohydrate Sequence
  • Galactosides (chemical synthesis)
  • Glycosides (chemical synthesis)
  • Mannosides (chemistry)
  • Molecular Sequence Data
  • Neoplasm Metastasis (prevention & control)
  • Oligosaccharides (chemical synthesis, chemistry)

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