Chemopreventive activity of crude hydroxsymatairesinol (HMR) extract in Apc(Min) mice.

Abstract	We studied the effects of a lignan, hydroxymatairesinol (HMR), and rye bran on intestinal tumor development in adenomatous polyposis colimultiple intestinal neoplasia (Apc)(Min) mice. HMR showed a strong chemopreventive effect in this animal model. The mean number of adenomas in the small intestine was significantly lower (26. 6+/-11.0, P<0.05) in mice fed the inulin and HMR when compared with the inulin and inulin/rye bran fed mice (39.6+/-8.9 and 36.0+/-7.4, respectively). HMR resulted in normalization of beta-catenin levels in adenoma tissue, indicating that HMR mediates its chemopreventive effect through the Apc-beta-catenin pathway. In the cytosolic fraction, beta-catenin level in adenoma tissue was significantly elevated (P=0.008-0.013) in all the diet groups as compared with that of the surrounding mucosa. In the nuclear fraction, beta-catenin in the inulin (3.15+/-2.9 relative units) and inulin/rye (5.17+/-6.94 relative units) groups was also significantly higher (P=0.003-0.009) in the adenoma tissue when compared with the surrounding mucosa (0.5+/-0.5 and 0.35+/-0.39 relative units). However, HMR was able to restore nuclear beta-catenin level of the adenoma tissue (0.41+/-0.25 relative units) to the level found in the surrounding mucosa (0.36+/-0.28 relative units).
Authors	S I Oikarinen, A Pajari, M Mutanen
Journal	Cancer letters (Cancer Lett) Vol. 161 Issue 2 Pg. 253-8 (Dec 20 2000) ISSN: 0304-3835 [Print] Ireland
PMID	11090976 (Publication Type: Journal Article)
Chemical References	CTNNB1 protein, mouse Cytoskeletal Proteins Furans Lignans Plant Extracts Trans-Activators beta Catenin Inulin
Topics	Adenoma (metabolism, prevention & control) Adenomatous Polyposis Coli (drug therapy, metabolism) Animals Body Weight (drug effects) Cell Nucleus (metabolism) Cytoskeletal Proteins (biosynthesis) Cytosol (metabolism) Furans (pharmacology) Intestinal Mucosa (metabolism) Intestinal Neoplasms (metabolism, prevention & control) Intestine, Small (pathology) Inulin (pharmacology) Lignans (pharmacology) Male Mice Mice, Inbred C57BL Mice, Mutant Strains Neoplasms, Experimental Plant Extracts (pharmacology) Secale Trans-Activators beta Catenin

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